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What is Ponatinib? • Ponatinib is used in adults to treat a type of blood cancer called chronic myeloid leukemia (CML), or Philadelphia chromosome positive acute lymphoblastic leukemia (ALL). • Ponatinib is usually given after other treatments have failed. • Ponatinib may also be used for purposes not listed in this medication guide. • Important Information • Ponatinib may cause heart or blood vessel problems that could lead to heart attack, stroke, or death. • Call your doctor or get emergency medical help if you have: chest pain spreading to your jaw or shoulder, shortness of breath, dizziness, severe stomach pain, swelling in your legs, sudden numbness or weakness, headache, or problems with vision or speech. • Ponatinib may also harm your liver. Call your doctor right away if you have upper stomach pain with loss of appetite, dark urine, bruising, or yellowing of your skin or eyes. Source : https://www.drugs.com/mtm/ponatinib.html
How should I take Ponatinib? • Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. • Ponatinib is usually taken once daily, with or without food. • Swallow the tablet whole and do not crush, chew, or break it. • You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results. • If you need surgery, tell the surgeon ahead of time that you are using ponatinib. You may need to stop using the medicine at least 1 week before a surgery. • Do not stop taking ponatinib or change your medication dose without your doctor's advice. • Store at room temperature away from moisture and heat. Source : https://www.drugs.com/mtm/ponatinib.html
What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Ponatinib? Grapefruit may interact with ponatinib and lead to unwanted side effects. Avoid the use of grapefruit products. Source : https://www.drugs.com/mtm/ponatinib.html
Ponatinib • Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. • Ponatinib may cause heart or blood vessel problems that could lead to heart attack or stroke. Call your doctor right away or get emergency medical help if you have: • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, feeling short of breath; • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or • signs of a blood clot--severe stomach pain, pain or swelling in your arms or legs, coughing up blood. • Call your doctor at once if you have: • dizziness, confusion, headache, change in mental status; • a seizure. Source : https://www.drugs.com/mtm/ponatinib.html
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