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Single dose for rabies pre-immunization

Single dose for rabies pre-immunization. P. Khawplod 1 , H. Wilde 2 ,T. Kamolthum 3 ,Visith Sitprija 1 . 1Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand. 2 Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.

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Single dose for rabies pre-immunization

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  1. Single dose for rabies pre-immunization P. Khawplod1 , H. Wilde2 ,T. Kamolthum3 ,Visith Sitprija1. 1Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand. 2 Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand. 3 Provincial Public Health Office of Pitsanulok , Thailand.

  2. The Ab response in incomplete PET cases(1 - 3 injections) All subjects received TRC-ID 2-2-2-0-1-1 (PVRV lot.no. L1012, potency 8.7 IU/0.5mL)

  3. Pre-exposure vaccination Shorten time & reduce cost

  4. Objective : To evaluate the immune memory of two abbreviated pre-exposure rabies vaccinationschedules

  5. Study 1 • One week schedule ( 3 injections on day 0,3,7) Study 2 • One clinic visit (Single dose)

  6. One week schedule Gr.A ID (2 sites) on day 0, 7 ,28 Gr.B ID (2 sites) on day 0, 3, 7 Gr.C IM on day 0, 3, 7 PVRV potency 7.5 IU/0.5 mL

  7. One week schedule Booster : ID (2 sites) on day 0,3 1 year later Blood collection : before booster (1 year) , 7 and 14 days PVRV potency 7.5 IU/0.5 mL

  8. Booster : ID(2 sites) on day 0,3 1 year later

  9. One injection for 1- 4 years( at QSMI )

  10. Conclusions: • 3 injections on day 0,3,7 is as immunogenic as 3 injections on day 0,7,28 • Provide at least 1 year of immune memory

  11. Single dose for rabies pre-immunization( one clinic visit )

  12. Pre-immunization ID 0.1 ml (2 sites) on day 0 Single dose for rabies pre-immunization Booster ( 1 year later ) ID 0.1 ml ( 2 sites ) on day 0, 3 PVRV lot no 0525 potency 7.5 IU/0.5mL

  13. Single dose rabies pre-immunization

  14. Single dose rabies pre-immunization Single dose injection

  15. Conclusion: • One clinic visit ( ID 0.1 ml (2 sites) one time) provide at least 1 year of immune memory

  16. Pre-immunization vaccination ID 0.1 ml (1 site) on day 0 Single dose for rabies pre-immunizationin Petchaboonprovince • Booster ( 1 or 3 years later ) ID 0.1 ml ( 1 site ) on day 0, 3 PCEC Lot no725potency 7.25 IU/mL

  17. Booster : ID 0.1ml (1 site) on day 0,3 1 year later

  18. Booster : ID 0.1ml (1 site) on day 0,3 3 years later

  19. Conclusions: • 3 injections on day 0,3 and 7 • One clinic visit • ID 0.1 ml ( 2 sites) one time Provide immune memory at least 1 year or more

  20. Application for rabies pre-immunization • reliable booster vaccination • long lasting • ???? NEED FURTHER STUDIES

  21. Thank you for your attention

  22. Preventions Animal control Bite Prevention PET = 100% Pre-exposure vaccination Exposed

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