GenScript ProBio: The World's Leading Biotech Company

1. TheIndustryLeaderinDevelopingReliable BiologicalReagentsandProducts www.GenScript.com GenScriptUSAInc.860CentennialAve.Piscataway,NJ08854USA Phone:1-732-885-9188 Toll-Free:1-877-436-7274 Fax:1-732-885-5878 linkedin.com/company/genscript-corporation twitter.com/GenScript facebook.com/GenscriptCorp MAKERESEARCHEASY

2. OurFootprint Establishedin2002, GenScriptisaleading biotechcompany empoweringscientists inover100countries. 01 02

3. MessagefromOurChairman DearResearcher, When we founded GenScript in 2002, we had one important mission in mind: to make research easy, so innovation in biology would accelerate. Having worked in scientific research for many years, I witnessed huge frustration with reagents made in laboratories; issues with quality, speed, and reproducibility caused many delays and cost us tremendous efforts. So by industrializing the making of reagents, GenScript leveraged the power of technology to make reliable, high-quality reagents with consistency and speed. This effort empowered researchers acrossvarious disciplines in life sciences withthecapabilities to achieve more with less. Todate,wehaveservedmanyclientslikeyouformorethan19years. Wehavedevelopedstate-of-the-arttechnologyplatforms,including the proprietary high-throughput oligo synthesis, GenPlusTMhigh-throughput gene synthesis, the MolecularCloudTMPlatform, PepPowerTM automatic microwave-assisted peptide synthesis, high-throughput gene-to-antibody expression, and the MonoRabTMsuper sensitive rabbit monoclonal antibody generation platforms. These advanced technologies shaped the pillars of our core competence and helped GenScript to become the world’s largest gene synthesis provider and a major player in customized reagent production. But, we are more than our technologies. We take pride in our deep understanding of researchers and laboratories, as we have over 1,800 employees with Ph.D. or Master’s degrees, comprising about 40% of our total team members. From the labs, for the labs: we always care about your research more than anyone else because we know that your success isour success. In the past decades, biology has taken giant leaps forward. Exciting innovations are happening in many areas, including next-generation sequencing, genome editing, synthetic biology, and immunotherapy. At GenScript, we firmly believe that we are at the dawn of a new age in whichrevolutionarybreakthroughsinbiologywillfinallysolvefundamentalissuesofourhumanity:fromcuringavarietyofdiseasesand cleaning our environment to providing us safe and sustainable sources of food, we are eventually making our planet a better place to inhabit. This presents a great opportunity as well as a responsibility for all of us in biological sciences. I am confident that we as a community can work togetherto take advantage ofthis opportunity to benefit allwhile sharing the burden ofthe responsibility that comes withit. Fromahumblebeginning,GenScripthascomealongway, ashavethebiologicalsciences.Iwanttothankeveryonewhohasworkedvery hard in laboratories worldwide to take us and science this far. It has been a long yet rich journey for us and you, too. We think no one should embarkonthisjourneyalone.Soweinviteyoutocontinuetotakeusalongwithyou,letussupportyourgrowth,andtogetherlet’sfurtheradvance thefrontiersofbiologytoachieveourmissionof'MakeHumansandNatureHealthierThroughBiotechnology'. GenScript’sStory Sincerelyyours, RobinMeng Chairman 04 03

4. CoreValues OurCulture OurOrigin Foundedin2002, inPiscataway, NewJersey,USA OurVision “Become the Most Trustworthy BiotechCompanyintheWorld” CustomerFirst Innovation PursuitofExcellence Win-WinCooperation OurMission “Make People and Nature HealthierThroughBiotechnology” OurPeople ~4,600employeesglobally Integrity Introspection 05 06

5. 2021 Opened a new R&D and productionfacilityinSingapore 2018 Legend Biotech BCMA program receivedINDclearanceinUSandChina 2015 OpenedanewHigh-throughput USFacility GenScriptBiotechlisted inHKEX(Stockcode:1548) History&MilestonesofGenScriptGroup 2013 Launched Bestzyme (subsidiary companyspecializedinindustrial syntheticbiologyproducts) 2009 Received$15 million dollar investment from KPCB/TBIGHealthcare 2002 FoundedinNewJersey,US 2017 2019 SubsidiarycompanyLegend Biotech New Biologics GMP CDMOR&Dcenter Launchedthefirstcustom genesynthesisplatform Legend Biotech and Janssen entered into collaborationontheBCMA 2020 LegendwaslistedonNASDAQ onJune5andbecomes China'sfirst CAR-Tstock program EstablishedEuropean& Asia-PacificDivisiontofacilitate globalstrategy 2014 Launched Legend Biotech (subsidiary companyspecializedin celltherapy) Acquired100%ofthe issued shares of CustomArray GenScript and Duke-NUS Medical School, launched first-in-the-world cPassTM SARS-CoV-2 Neutralization AntibodyDetectionKit CAR-TproductsreceivedOrphan Drug Designation (FDA) and wererecognizedasbreakthrough therapy; clinicaldatashoweda 100%remissionrate BCMAprogramreceived OrphanDrugDesignation (FDA)&PRIME Designation(EMA) 2011 Opened a new R&D and productionfacilityinNanjing CROLeadershipAward 2004 Establishedcustomproteinand antibody services, R&D and productionsiteinNanjing,China Finishedtheconstructionofthe world's largest customized peptideservice platform Launched GenScript ProBio (specializedinbiologicsCDMO) EstablishedsubsidiaryinJapan 07 08

6. OurScienceEngine OurHumanEngine BasicResearch SyntheticBiology ProteinandAntibodyEngineering GeneandCelltherapy Diagnostics OligoSynthesis GeneSynthesis CoreTechnology Platform GenScriptGrowswhenour PeopleGrow FromtheLabs,FortheLabs Antibody,Protein and CatalogProducts 1,800+employeesholdM.S.andPh.D.degrees Various research and professionalopportunities availableforourteammembers toadvancetheircareer EnablingPlatformsfor DiverseBiomedical and IndustrialApplications ReshapingMillions of EverydayLives 09

7. Awards&Achievements Awards CROLeadershipAwardinProductivityandRegulatoryAffairs GenScriptLifeScienceCapabilities Recipientofthe 2018CiteAbMostPopularCustomAntibodySupplierAward GeneSynthesis Recipientofthe 2020CiteAbEnvironmentalInitiativeAward forTree PlantingProgram One of the five founding members of the International Gene Synthesis Consortium (IGSC) Theonly commercialentityinvitedtoparticipateintheSyntheticYeastGenomeProject OligoandCRISPR PeptideSynthesis AwardedISO9001,ISO13485,AAALAC,and OLAWcertificates Services ReshapingMillions ofEverydayLives 2018GoldenLionAwardwinnerforBestInnovativeListedCompany,sponsoredbySinaFinance CitationsofGenScript'sServices& Products 8,000 7,000 6,000 5,000 4,000 3,000 2,000 1,000 0 ResearchReagents ProteinProduction andEquipment AntibodyDevelopment 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 09

8. Capabilities:SyntheticBiology Capabilities:MolecularBiology One-stopSolutionForAllYour CustomGeneSynthesisNeeds FromGeneSynthesisTo PlasmidPrep Largestgene provider since2008 FAST, RELIABLE ANDEFFICIENT High-qualityplasmids,from researchtopreclinical grade, supported by fully automated platforms PLASMID DNA PREPARATION 99.95%successrate >99%on-timedeliveryrate GenBrickTM–DNAupto200kb Proprietarytechnologyforaccurateand efficientone-stepassemblyDNAfragments Accelerate the build phase of yourproject with high-throughput,seamlessly assembled constructs HTDNAASSEMBLY LIBRARY Diverse, unbiased mutant libraries for precision engineering of proteins, enzymes, andmore PRECISIONMUTANT LIBRARIES GenSmart™Platforms IntelligentapproachtoyourDesign, OptimizationandInstantQuoteprocesses Automated,high-throughput platformsforlargevolume, complexDNAsequences synthesisupto200kb GENESYNTHESIS VectorArkTMandCloneArkTM Reliably Archive, Share and Reuse on a single platform 13 14

9. Capabilities:GenomeEditing Capabilities:PeptideSynthesis DedicatedTeam ofProfessionals 170ProductionScientists 20R&DScientists >50% of Team Members with >3 years of PeptideSynthesisExperience UnmatchedQualityControl andQualityAssurance AccuPepQC+ ISO9001:2015Certified Total QualityManagement One-StopCRISPRReagents&Services PoweredbyhighpuritysgRNA,Cas9protein,andssDNAHDRtemplatessynthesiscapabilities PepHTSTMLibraryPlatform FastTurnaroundTime High-Throughput Flexible Service ReliableQuantity ProprietaryTechnology NeoPreTMAlgorithm HiSynTMTechnology >16PatentsforPeptideServices FromScreeningTo PreciseEditing FromBasicResearchTo Gene&CellTherapies From Discovery To EarlyClinicalStudies 15 16

10. Capabilities:High-EfficiencyCustomAntibodyGeneration Capabilities:TransientMammalianExpression Higher positive clone rates and diversity with B-cellcloning 3 1 5 Target Validation InvitroandIn vivotesting GLPSafety IND Antigen-Positive B Cell Enrichment&Expansion Screening & Supernatant Harvest Antibody Sequencing & SmallScaleTransfection RecombinantAntibody Production Immunization PBMC isolation 2 4 6 NNoonn--GGLLPP SSaaffeettyy “Hits” Screening Clinical & Commercial AchieverabbitmAbsidealfor yourresearchapplicationsin asfast as13weeks! LeadIdentification LeadOptimization Manufacturing Accelerated Monoclonal Antibody DiscoveryviaSingleBCellScreening Rapidlyidentifyadiverserepertoireofhigh-affinitymAbs within24hours! CHObasedexpression HEK293basedexpression High-DensityHEK293-FExpression High-throughput, automated Optofluidic™ screening technology via the Beacon® Platform Access >99% of antibody repertoire for maximal mAb diversity IdealforIVDimmunoassaydevelopmentanddifficultimmunogens High-DensityCHOExpression High-Density(HD)Transient MammalianExpressionServices LetourExperts unleashthefull potentialofyourrecombinant antibodyexpression 17 18

11. Capabilities:ViralVectorsforCellEngineering Capabilities:ViralVectorsforCellEngineering High-EfficiencyViralVector Packaging Maximal production efficacy Intact,functionalviralparticles Highlycustomizableviraltitersandvolumes High-QualityLentivirusparticles Superior performance Bettertransductionefficacy PhysicalTiter FunctionalTiter Side-by-side comparison of GenScript and Competitor Lentiviruses bearingGFP-reporter genes Multiplephysicaland functional viral titer methodsavailable Bright Field qPCR p24 ELISA FlowCytometry AntibioticSelection Flowcytometry(TU/ml) Antibioticselection(TU/ml) p24ELISA(IFU/ml) Optimal production protocol ensuresconsistenttiterresult Superior Performance: GenScript Lentiviruses have a better transduction efficacy as indicated by higher proportion of GFPpositivecells GFP 3 4 ViralTiter(108/ml) 0 1 2 5 6 7 8 20 19

12. GenScriptLifeScienceApplications Enablingplatformsfordiversebiomedical andindustrial applications Protein andAntibody Engineering GeneandCellTherapy Diagnostics BasicResearch Biopharmaceutical Synthetic Biology 22 21

13. Applications:BasicResearch Applications:Protein andAntibody Engineering GenScriptisTHE#1geneprovider Synthesizing30%ofallsyntheticgenesworldwide GenScriptprovidesaseriesofmolecularbiology,protein,andantibody drug discovery solutionstohelpmaximizethesuccessof yourproteinandantibodyengineeringprojectsandhelpyouaccomplishmoreinyourresearch. Application Note: GenScript offers high-quality mutant libraries, called Precision Mutant Libraries, for various protein and antibody engineering interests. These libraries enable codon optimization, elimination of stop or unwanted codons, incorporation of user-defined codons, and even distribution of amino acids with little bias. Such smart libraries contain only desired mutants, thus saving valuable time and effort during the screening and characterization process,speedinguptheengineeringworkflow,andreducingtheoverallcostofdownstreamexpenses. Plasmid Preparation Gene Synthesis Premium Reliable Unmatched Target-SpecificAntibodies withHighAffinities AntibodyLibrary PrecisionMutantLibrary (DNA) Target Screen Express Gene Variant Libraries Mutagenesis &Cloning substrate substrate substrate substrate 600,000+projects delivered >100,000customersfrom over100countries >64,700publications cited DirectELISA IndirectELISA SandwichELISA CompetitiveELISA 23 24

14. Applications:Diagnostics Applications:Gene&CellTherapy Syntheticbiology-baseddiagnosticsprovidereal-time,dynamic,sensitive,highly-specific,andnon-invasive methods for detecting and monitoring cancer cells, metabolic parameters, infectious agents, therapeutics, and exposure to toxins. The development of dual-functioning diagnostic-therapeutic platforms is also changing the definition and application of diagnostics in medicine towards a more comprehensive and integrated approachin patient care. Recent advances and successes in CAR T discovery have demonstrated its great potential for treating various cancers, especially blood cancers. With the maturation of CRISPR/Cas9 technology,itisnowpossibletoinsertlargegenesatspecificgeneticsitesinhumanprimaryTcellsforCAR expressionwithout using viral vectors. gRNAdesign and commercial synthesis (1Week) RNPFormation (1Hour) HDRtemplatedesign HDRtemplateproduction (2-3 Weeks) Electroporation (30Minutes) 96-well electroporation conditions Assayviabilityand efficiency (GFPexpression) Cellharvestand resuspension (15Minutes) TCellisolationand stimulation (2Days) Species Independent Isotype Independent High Specificity High Sensitivity Safe & Scalable Star Product: The GenScript cPass™ SARS-CoV-2 Neutralization Antibody Detection Kit, also known as SARS-CoV-2 Surrogate Virus Neutralization Test(sVNT) Kit, is the first-in-the-world "rapid smart test kit", with the capability of measuring functional neutralizingantibodies (NAbs) within an hour in mostresearch or clinical labs. GenScript has acquired CEmark (Europe) and HSAprovisional approval (Singapore) andhas been issuedEmergency UseAuthorization (EUA) by U.S. FDA. Case Study：This case study demonstrates the benefits of using long single-stranded DNA (ssDNA or ssODN) as non-viral CRISPR HDR templates in T cell engineering. To make ssDNA more readily available for cutting-edge researchers, GenScript has developed proprietaryenzymatic approaches for producing ssDNAs withnon-detectable levels of dsDNAand minimum DNAbase damage. 25 26

15. MadeinUSA Infrastructure:HTUSFacility IntroducingOurNewHigh-ThroughputUSFacility 50,000 sq. ft. of Cutting Edge Technology to bring you FASTER, MORE CONSISTENT ANDSUPERIOR SERVICES Nowclosertoyou Poisedtodeliver >4millionbasepairs/month >4000genes/month >19yearsofexperience LocatedinPiscataway,NJ SupplyChainResiliency 8 DayTurnAroundTime FullyAutomated Production Teamofdedicated professionals 10Xcapacityexpansionmadepossibleby >10 automated liquid handlers Full768Oligosynthesizers Inthetrustedhandsof70 Ph.D.levelprofessionals 27 28

16. Innovative Products:Protein andAntibody Purification InnovativeProducts:One-StopSolutionforProteinAnalysis Reduce Antibody Purification Time from Days to Hours withtheAmMag™MagbeadsPurificationPlatform Automated western blotting witheZwestTM Fast Automatic Efficient 0.5 s Fast Imaging with ePhotoTMimager 10minprotein transferwitheBlotTM AmMagTMMagneticRacks AmMagTMProteinAMagneticBeads (Alkaline-resistant) 70% Faster&Easier Fast Automatic Efficient AmMagTMSAPlusAutomated ProteinPurificationSystem AmMagTMMagneticBox 10mingelstaining witheStainTM 20+ min gel separation withSurePAGETM 29 30

17. Programs&Partnerships Spotlight on Customers’Success Over19YearsofPartnership Morethan64,700successfulcustomerresearch publicationsinhigh-impactjournals e r e R P e t c n o a g t n s i n t I i o @GenScript n Thanks to the supportand help ofGenscript pr ovides,the success oftheactivities.@Genscript P l y a r s o t m i s i d o p R e Apremium partner ofthe International Genetically Engineered Machine (iGEM) Competition that awards and trains the most innovative synthetic biologists. MolecularCloudTMis a free and centralized online platform, featuring a biological material repository, conversation panel, and CloudScientistprogram to support and connect the worldwide research community beyond scientificachievements. CRISPR/Cas9 Licensing Agreement with Broad Institute and ERS Genomic to enhance our CRISPR offering for gene andcelltherapyresearch. GenScript Scholar Club Program promotes and rewards scientific accomplishments of GenScript’scustomers acrosstheglobe. 194in Cell 177in Nature 539inPNAS our customers’ innovative drive and hard work ourreliablecustomizedservicesandproducts Allmadepossibleby 31 32