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FA FA-CoA FA metabolite PowerPoint Presentation
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FA FA-CoA FA metabolite

FA FA-CoA FA metabolite

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FA FA-CoA FA metabolite

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  1. Scheme for PPARA regulation of gene transcription FA FA-CoA FA metabolite Inflammation: (IL1B, TNFA, IL6, IL12A, MCP1) Amino acid metabolism (GPT) Fatty acid activation: (FCAL2) Corepressor complex HDAC Coactivator complex HAT Lipogenesis: (FADS, ME) RXR RXRL RXRL Ketogenesis:(HMGCS2) PPAR RXR PPAR X AGGTCANAGGTCA TCCAGTNTCCAGT AGGTCANAGGTCA TCCAGTNTCCAGT Lipolysis: (LPL) PPRE (DR1) PPRE (DR1) Biotransformation: (UGT1A9,ADH3) Cholesterol catabolism: (CYP7A1,LXRA) Oxidation: (ACOX1,CPT1A,CPT2,MCAD,SCP-X) Fatty acid binding and transport: (FABP1,ACBP,FATP1) Ordovas J Nutrigenetics, plasma lipids and cardiovascular riskJ Am Diet Assoc. 2006; 106 Lipoprotein metabolism: (APOA1,APOA2,APOA4,APOA5,APOC3,PLTP,PPARA)