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This article by Lemere and Masliah (2010) explores the potential of amyloid-β immunotherapy for Alzheimer's disease prevention. It compares active and passive immunization methods, discussing their mechanisms, efficacy, and challenges. The study highlights the importance of targeted immunization strategies in Alzheimer's research and provides insights into developing effective therapies that could mitigate disease progression. The authors critically assess current findings and propose future directions for research in immunotherapeutic approaches.
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Figure 1 Active and passive immunization approaches Lemere, C. A. & Masliah, E.(2010) Can Alzheimer disease be prevented by amyloid‑β immunotherapy? Nat. Rev. Neurol. doi:10.1038/nrneurol.2009.219