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This article explores the regulatory function of the miR-93/Sp7 loop in osteoblast mineralization, highlighting how miR-93 influences the expression of Sp7 and associated mineralization target genes. Impaired osteoblast mineralization is discussed, focusing on the critical interactions between miR-93 and Sp7. The implications for understanding bone health and the potential pathways for therapeutic intervention are also considered, making this study essential for researchers in bone biology and related fields.
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miR-93/Sp7 function loop mediates osteoblast mineralization • Osteoscoop - Issue N°264 – November 2012
Osteoblast mineralization Sp7 + Mineralizationtargetgenes SP7
Osteoblast mineralization Sp7 + Mineralizationtargetgenes SP7 Mineralizationtargetgenes miR-93 SP7 Impaired osteoblast mineralization
Osteoblast mineralization Sp7 + Mineralizationtargetgenes - SP7 - SP7 - miR-93 Mineralizationtargetgenes miR-93 miR-93 SP7 Impaired osteoblast mineralization