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Sparse-sampling PK study (4 samples) Interim analysis; n = 43 (n = 28 EFV, n = 15 ATV/RTV)

Tenofovir (TFV), Emtricitabine (FTC), Intracellular Metabolite (TFV- dp , FTC- tp ), and Endogenous Nucleotide ( dATP , dCTP ) Concentrations as a Function of Aging in HIV+ Subjects. Sparse-sampling PK study (4 samples) Interim analysis; n = 43 (n = 28 EFV, n = 15 ATV/RTV)

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Sparse-sampling PK study (4 samples) Interim analysis; n = 43 (n = 28 EFV, n = 15 ATV/RTV)

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  1. Tenofovir (TFV), Emtricitabine (FTC), Intracellular Metabolite (TFV-dp, FTC-tp), and Endogenous Nucleotide (dATP, dCTP) Concentrations as a Function of Aging in HIV+ Subjects • Sparse-sampling PK study (4 samples) • Interim analysis; n = 43 (n = 28 EFV, n = 15 ATV/RTV) • Hypothesis: chronologic age alone is not a predictor of PK changes in older HIV+ subjects • Fried frailty phenotyping, p16INK4a expression analysis • Calculated area-under-the-concentration-time-curve (AUC) for TFV, FTC, TFV-dp, FTC-tp, dATP, dCTP, EFV, ATV, RTV • Tested for associations with subject characteristics, frailty, p16INK4a expression • Report intracellular metabolite concentration: endogenous nucleotide ratios

  2. Results- Statistical Analysis

  3. Results- Endogenous Nucleotides p<0.02 for association of dATP AUC and regimen TFV-dp: tenofovir diphosphate; dATP: deoxyadenosine triphosphate FTC-tp: emtricitabine triphosphate; dCTP: deoxycytidine triphosphate

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