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2014 Cancer Center Administrators Forum

2014 Cancer Center Administrators Forum. San Diego NCI C ancer C enters C ouncil ( C3 ) : A Model for Multi‐Institutional Transdisciplinary Collaboration. Scott M. Lippman, MD Director, Moores Cancer Center April 14, 2014. Evolution of the Moores Cancer Center.

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2014 Cancer Center Administrators Forum

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  1. 2014 Cancer Center Administrators Forum San Diego NCI Cancer Centers Council (C3): A Model for Multi‐Institutional Transdisciplinary Collaboration Scott M. Lippman, MD Director, Moores Cancer Center April 14, 2014

  2. Evolution of the Moores Cancer Center Strategic Recruits Cancer Center Founded John Mendelsohn, Director Napoleone Ferrara Basic Science Ezra Cohen Translational Science UCSD SOM Founded Moores Cancer Center Opened Razelle Kurzrock Clinical Science ‘14 Dennis Carson Director CCSG Renewed CTSA Awarded NCI-designated Cancer Center CCSG Renewal Awarded Comprehensive Status Scott Lippman Director 2

  3. UCSD Moores Cancer Center External Advisory Board Senior Advisor to the Director Thomas Kipps, MD, PhD Executive Committee Center Director Associate Vice Chancellor for Cancer Research and Care Scott Lippman, MD Deputy Director Barbara Parker, MD Cancer Cabinet Administration Ira Goodman, MPA, MS Board of Visitors Shared Resources Nicholas Webster, PhD Division of Clinical Science Razelle Kurzrock, MD Division of Population Science John Pierce, PhD Division of Basic Science Napoleone Ferrara, MD Shared Resources Nicholas Webster, PhD Division of Clinical Science Razelle Kurzrock, MD Division of Population Science John Pierce, PhD Division of Basic Science Napoleone Ferrara, MD • Research Programs • Cancer Prevention • Reducing Cancer • Disparities • Research Programs • Hematologic • Malignancies • Solid Tumor • Therapeutics • Research Programs • Cancer Biology • & Signaling • Cancer Genomics • & Networks Shared Resources (7) Biorepository & Tissue Technology Biostatistics Genomics & Bioinformatics Microscopy Flow Cytometry Transgenic/KO Mice Diet & Physical Activity Office of Industry Relations Clinical Trials Office 3

  4. FACILITIES Moores and Other Cancer Center Facilities on the UC San Diego Campus Relation to Consortium Partner SDSU Cancer Campus MCCMoores Cancer Center CALM Center for Advanced Laboratory Medicine Altman CTRI CALM SCRM JMCJacobs Medical Center - Hospital for Cancer Care CTRIClinical and Translational Research Institute JMCHCC SIO OP LICR MCC OP Outpatient Pavilion CNT Center for Novel Therapeutics CNT SCRM Sanford Consortium for Regenerative Medicine LICR Ludwig Institute for Cancer Research SIOScripps Institution of Oceanography 4

  5. Catchment Area REGIONAL IMPACT San Diego • 8th Largest city (1.33M) • 5th Largest county (3.14M) Imperial County • Population = 175K • Poverty Rate = 23% UCLA USC City of Hope UC Irvine AZ Cancer Center 121 miles MCC 410 miles 5

  6. Sanford Consortium for Regenerative Medicine (opened Dec 2011; LIAI, Salk, S-B, MCC, TSRI) Clinical Hub of Unique Biomedical Environment LIFE TECHNOLOGIES (C3 MOU signed Oct 2012) AMGEN JANSSEN NOVARTIS THE SCRIPPS RESEARCH INSTITUTE PFIZER SCRM SALK SALK SANFORD | BURNHAM UCSD MOORES SANFORD | BURNHAM LA JOLLA ALLERGY AND IMMUNOLOGY • San Diego State University • (Formal consortium MOU signed Apr 2013) SDSU SDSU JCVI JCVI MERCK • J. Craig Venter Institute - HLI • (opened Nov 2013; HLI MOU signed Feb 2014) ILLUMINA 16 miles • 2nd largest life-sciences cluster in US (Jones Lang LaSalle) • Advisory & Innovation Council • Center for Novel Therapeutics (CNT) 6

  7. MCC / C3Formal Affiliations / Timeline HLI MOU signed (Feb 2014) Salk Gene Transfer Targeting S-B High Throughput Screening MCCBiorepository C3 Pilot Grant Awards (May 1, 2014) JCVI opened on UCSD Campus (Nov 2013) Pedal the Cause Fundraiser (Oct 26, 2013) SDSU: Formal consortium w/ MCC MOU signed (Apr 2013) C3 Reception at AACR (Apr 7, 2014) C3 MOU signed (Oct 12, 2012) 2012 2013 2014 Members from TSRI, LIAI & JCVI join MCC faculty Sanford Consortium for Regenerative Medicine (SCRM) opens (Dec 2011) C3Pilot Grant RFA (Feb 28, 2014) C3Retreat (June 29, 2013) SDSU: Federally-designated Hispanic-serving Institute (April 2012) Mahajani Symposium (Sep 9, 2013)

  8. C3 Steering Committee • Chair(rotating) • Scott M. Lippman (UCSD Moores) * • Co-Chairs • Tony Hunter (Salk) • Garth Powis(Sanford-Burnham) • * All three Institutes are represented on the AACR Board of Directors in 2014 • Members • Webster Cavenee (UCSD Moores) • David Cheresh (UCSD Moores) • Barbara Parker (UCSD Moores) • Ron Evans (Salk) * • InderVerma (Salk) • Geoff Wahl   (Salk) • Sara Courtneidge (Sanford-Burnham) • Ze’evRonai (Sanford-Burnham) • KristiinaVuori (Sanford-Burnham) * • Ira Goodman (UCSD Moores) • A.D. Admin

  9. C3 Resource Sharing Participating SRs: • Negotiated an agreement to share unique resources at each institution that are unavailable at the other 2 Cancer Centers (CC) • All institutions agreed to give CC members, no matter the institution, the same priority and rates as internal CC users • Institutions agreed to reduce the IDC charged to users from the other 2 CC Moores: from 45% to 16% (SOM Dean agreed to waive 29% academic portion) Salk: from 95% to 16% SBMRI: from 35% to 16% • CC agreed to cover IDC (16%) using developmental funds from their respective CCSGs (not part of formal agreement) • All institutions agreed that standard services provided by the shared resources would not involve intellectual property • C3 agreement has increased usage of the three cores by users at the other CCs during the first year

  10. C3 Scientific Retreat: June 29, 2013 • Keynote Address • Tony Hunter, PhD • “Tyrosine Kinases in Cancer Biology • and Treatment: Past, Present, Future” UC San Diego Moores Cancer Center – Biorepository Core Shared Resources Director Nicholas Webster, PhD Core Leader Scott VandenBerg, MD, PhD Core Users Clark Chen, MD, PhD Frank Furnari, PhD Michael Karin, PhD Andrew Lowy, MD • Sanford | Burnham Cancer Center • – High Throughput Screening Core • Shared Resources Director • Craig Hauser, PhD • Core Leader • Michael Jackson, PhD • Core Users • Matthew Petroski, PhD • Jeffrey Smith, PhD • Robert Wechsler-Reya, PhD CANCER CENTERS COUNCIL • Salk Cancer Center • – Gene Transfer Targeting and Therapeutics Core • Shared Resources Director • James Fitzpatrick, PhD • Core Leader • LeszekLisowski, PhD • Core Users • Jan Karlseder, PhD • Ben Spike, PhD

  11. Support for C3 Team Science

  12. C3 Website & Pilot Grant RFA www.sdcancercouncil.org

  13. C3 Pilot Grant Applications new

  14. San Diego NCI Cancer Centers Council (C3): A Model for Multi‐Institutional Transdisciplinary Collaboration Scott M. Lippman, MD Director, Moores Cancer Center Chugai Pharmaceutical Chair, Professor of Medicine Associate Vice Chancellor for Cancer Research and Care

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