SlideServe
Télécharger Obtenir Pro
Menu
Accueil Pro
Préférences
ApparenceLight Aide et commentaires
© SlideServe · v2026

NSAIDs

gordy avatar
gordy
14 diapositives · 729 Views · Jul 18, 2014

NSAIDs. What will be covered. Indications Mechanism of action Side Effects Contraindications Metabolism Pharmacokinetics. Indications. Analgesia Anti-inflammatory Anti-pyretic. Mechanism of Action. Leukotrienes. Lipo-oxygenase. Thromboxane. Phospholipids. Arachidonic acid.

#nsaids #nsaids ppt #powerpoint #presentation
NSAIDs - slide 1
01 / 14NSAIDs
1 / 17

Télécharger la présentation

NSAIDs
Une image / un lien ci-dessous est fourni (tel quel) pour télécharger la présentation

Politique de téléchargement : le contenu du site vous est fourni TEL QUEL pour votre information et votre usage personnel ; il ne peut être vendu, concédé sous licence ni partagé sur d’autres sites sans l’accord de son auteur.Le contenu vous est fourni TEL QUEL, pour votre information et votre usage personnel uniquement. Téléchargez la présentation en cliquant sur ce lien. Lors du téléchargement, si vous ne parvenez pas à télécharger une présentation, l’éditeur a peut-être supprimé le fichier de son serveur.Pendant le téléchargement, si vous ne parvenez pas à obtenir une présentation, le fichier a peut-être été supprimé par l’éditeur.

F I N

Plus de contenu associé

Transcription de la présentation

  1. NSAIDs

  2. What will be covered • Indications • Mechanism of action • Side Effects • Contraindications • Metabolism • Pharmacokinetics

  3. Indications Analgesia Anti-inflammatory Anti-pyretic

  4. Mechanism of Action Leukotrienes Lipo-oxygenase Thromboxane Phospholipids Arachidonic acid Tx Synthase Phospholipase A2 COX Prostaglandin A2 PG Synthase Prostaglandins

  5. Analgesia • Prostaglandins sensitize noiceptor endings to inflammatory mediators. • NSAIDs will prevent the noiceptor endings becoming sensitive to inflammatory mediators through the blockade of prostaglandin synthesis.

  6. Anti Inflammatory • When inflammatory cells are activated COX-2 is induced. • COX-2 initiates the eicosanoid mediators of inflammation. • Through the blockade of eicosanoid production NSAIDs reduce; vasodilation and therefore oedema and pain.

  7. Mechanism of Action Eicosanoids Leukotrienes Lipo-oxygenase Thromboxane Phospholipids Arachidonic acid Tx Synthase Phospholipase A2 COX Prostaglandin A2 PG Synthase Prostaglandins

  8. Anti Pyretic • IL-1, IL-6 and TNF function as endogenous pyrogen. • These cause the hypothalamus to raise the body temperature by releasing prostaglandins. • Through the blockade of prostaglandin production in the hypothalamus, the body temperature remains stable.

  9. Side Effects • Gastric Side Effects • PG E-2 decreases gastric acid secretion. • PG E-2 increases gastric mucus secretion. • If prostaglandins are inhibited, gastric acid secretion increases and gastric mucus secretion decreases. • This may lead to gastric ulcer formation.

  10. Side Effects • Renal Side Effects • NSAIDs do not have an effect on those with normal kidney function. • Those with poor kidney function can be affected by acute renal insufficiency, which is reversible on stopping the drug. • Neonates and the elderly are particularly effected. • The prostaglandins PG I-2 and PG E-2 have a role in vasodilation in response to angiotensin II and noradrenaline.

  11. Contra Indication and Cautions • Heart failure or pre-existing cardiac morbidity; NSAIDs should be used with caution due to their potential effects on kidney. • Hepatic impairment; increased risk of gastric irritation. • Pregnancy; manufacturers suggest that they shouldn’t be used. • Use in the third trimester can lead to premature closure of the ductusarteriosus leading to pulmonary hypertension.

  12. Metabolism and Pharmacokinetics • Metabolised in the liver by oxidation to non reactive species. • Excreted in urine • Ibuprofen and Diclofenac have a short half life of only 2-3 hours