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Impact of Methyltransferase Activity on Tau Hyperphosphorylation and Neuronal Death

This study explores the relationship between S-Adenosylhomocysteine (SAH), S-Adenosylmethionine (SAM), and the activity of methyltransferases in the context of tau phosphorylation and neuronal cell death. Elevated levels of SAH and the consequent DNA hypomethylation were linked to increased tau hyperphosphorylation and amyloid precursor protein processing. The results indicate that both active and inactive PP2A, along with kinases and presenilin overexpression, play significant roles in these pathways, ultimately contributing to neurodegenerative processes.

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Impact of Methyltransferase Activity on Tau Hyperphosphorylation and Neuronal Death

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  1. SAH SAM regulatory subunit CH3 B B Methyltransferase A C A C A C Active PP2A Inactive PP2A SAH P-tau Tau ATP Kinases ADP + Presenilin 1 -amyloid Amyloid precursor protein Secretases overexpression + HCY DNA-hypomethylation Accumulates Neuronal death  SAH or SAM Supplemental Data Figure 1

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