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1. C. Darwin & A. Wallace  Blending

Genetics. I . Introduction. A. History. 1. C. Darwin & A. Wallace  Blending. 2. G. Mendel & F. Unger  Mixing. 3. W. Sutton  Chromosomal Theory of Inheritance. 4. T. Morgan  Genes & Chromosomes plus linkage groups. 5. A. Sturtevant  Genetic Mapping.

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1. C. Darwin & A. Wallace  Blending

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  1. Genetics I. Introduction A. History 1. C. Darwin & A. Wallace  Blending 2. G. Mendel & F. Unger  Mixing 3. W. Sutton  Chromosomal Theory of Inheritance 4. T. Morgan  Genes & Chromosomes plus linkage groups 5. A. Sturtevant  Genetic Mapping 6. F. Griffith  Hereditary molecule 7. A. Jefferys  DNA finger printing 8. 2003  human DNA sequenced

  2. II. Mendelian Genetics A. Experimental Design 1. Monohybrid Cross a. Definition b. Terms i. Self vs. Cross Fertilization ii. Traits vs. Characteristics Figure 9.2D

  3. c. Process Figure 9.2C Figure 9.3A

  4. Figure 9.4 Figure 9.3B d. Principle  “Law of Segregation”

  5. e. Terms i. Gene versus Allele iii. Dominant versus Recessive iv. Genotype versus Phenotype ii. Homozygous versus Heterozygous

  6. f. Testcross Figure 9.6

  7. 2. Dihybrid Cross a. Definition i. Start by figuring out the parents genotypes b. Process ii. Then how many and type of gametes Figure 9.5A

  8. Practice Dihybrid Heterozygous cross = AaBb X AaBb Gametes AaBb = AB, Ab, aB, & ab for both Phenotypic ratio= 9:3:3:1, Genotypic ratio= 1:1:2:2:4:2:2:1:1 Dihybrid Heterozygous cross Homozygous Dominant = AaBb X AABB Gametes AaBb = AB, Ab, aB, & ab; AABB= AB only Phenotypic ratio = all dominant, Genotypic ratio = 1:1:1:1 c. Principle  “Law of Independent Assortment”

  9. III. Variation on Mendel A. Dominance 1. Complete 2. Co-dominance AA aa Aa

  10. 3. Incomplete dominance Figure 9.11A

  11. B. Gene Interactions 1. Multiple Alleles 2. Pleitrophy Figure 9.13B Figure 9.12 3. Penetrance

  12. C. Beyond Mendel 1. Epistasis 2. Polygenic Figure 9.14

  13. IV. Classical Genetics A. History 1. R. Punnet & W. Bateson  1908 Figure 9.7

  14. 2. T. Morgan  Genes & Chromosomes, Karyotyping, plus linkage groups a. Drosophila melanogaster WHY? Figure 9.18C

  15. b. Genetic Recombination Figure 9.18A Figure 9.18C

  16. 3. A. Sturtevant a. Genetic Mapping Based on frequency of expression of traits showing together Figure 9.19A Figure 9.19B Figure 9.18C

  17. B. Sex Linkage 1. Sex Linked Inheritance Figure 9.20A Figure 9.20 B - E Figure 15.7

  18. 2. Barr Bodies Figure 11.2B

  19. V. Detection of Problems A. Techniques 1. Karyotyping 2. Amniocentesis == Cellular and Chemical Analysis Figure 9.10A

  20. 3. Ultrasound Figure 9.10B

  21. 4. Chorionic Villi Sampling == Cellular and Chemical Analysis Figure 9.10A

  22. 5. Fetal Tissue Sampling

  23. 6. Pedigree Analysis Figure 9.8A & B

  24. Figure 9.22

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