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Understanding Physiologically Based Pharmacokinetic (PBPK) Modeling for Drug Development

Physiologically Based Pharmacokinetic (PBPK) modeling combines biology and mathematics to predict how drugs are absorbed, distributed, metabolized, and eliminated (ADME) in the body. This advanced modeling technique is essential in pharmaceutical research and health risk assessments for various substances, including drugs and cosmetics. By simulating the physiological structure through compartments corresponding to organs and tissues, PBPK models can accommodate changes in ADME with age, species, and exposure levels. This guide outlines PBPK's use cases, model structure, and applications in predicting biological responses.

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Understanding Physiologically Based Pharmacokinetic (PBPK) Modeling for Drug Development

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Presentation Transcript

  1. IRISPCPBPIKDAMPPBPKDMACPBBHTCPDDTPCBPELPPHBAP

  2. Outline • What is PBPK? • Uses of PBPK • Model structure • Examples

  3. PBPK • Physiologically Based PharmacoKinetic • Predicting absorption, distribution, metabolism and elimination (ADME) • Exposure → effects • Linear • Probit

  4. When to use • ADME changes with time or age, species, exposure level or between individuals

  5. Uses of PBPK • Pharmaceutical research (drugs) • Health risk assessment (cosmetics, toxins)

  6. Model structure • Mathematical compartment model • Mechanistic • A priori – anatomy, physiologial structure

  7. Model structure • Compartments for organs and tissues • Transfers for blood or lymph flows • Parameters for blood flow rate, ventilation rate, organ volume

  8. Model structure • Inputs: inhalation, ingestion, dermal exposure, injection • Outputs: excretion, exhalation, degradation, metabolism

  9. Model structure Cven.blood ·Fblood VeneousBlood Cmuscle ·Fmuscle Muscle Cart.blood · Fmuscle ArterialBlood

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