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DNA Repair Mechanisms in Human Cell Lines: Insight from Protein Study

Analyzing protein interactions in UDG-treated HeLa, Ramos, LoVo cell lines reveals repair mechanisms. Evaluation of substrate-product transformation and repair efficiency highlights differences between Ugi-treated and untreated cells.

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DNA Repair Mechanisms in Human Cell Lines: Insight from Protein Study

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  1. A Protein: No UDG HeLa Ramos LoVo Ugi:- - - + - + - + 50-mer substrate 29-mer product B HeLa Ramos Ugi:- + - + 7.3 kb unrepaired 4.2 kb repaired 3.1 kb % repaired: 52% 35% 64% 32%

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