NIAID Commitment to Influenza Research and Preparedness F. Gray Handley Associate Director for International Research Affairs National Institute of Allergy and Infectious Diseases National Institutes of Health January 28-31, 2007
U.S. Department of Health and Human Services The Secretary Deputy Secretary Administration for Children and Families (ACF) Administration on Aging (AoA) Food and Drug Administration (FDA) Health Resources and Services Administration (HRSA) Centers for Medicare and Medicaid Services (CMS) Agency for Health Care Policy and Research (AHCPR) Indian Health Services (IHS) National Institutes of Health (NIH) Centers for Disease Control and Prevention (CDC) Agency for Toxic Substances and Disease Registry (ATSDR) Substance Abuse and Mental Health Services Administration (SAMHSA) Program Support Center (PSC)
National Institutes of Health Office of the Director National Institute of Allergy and Infectious Diseases National Institute on Aging National Institute o Alcohol Abuse and Alcoholism National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Institute of Biomedical Imaging and Bioengineering National Center for Complementary and Alternative Medicine National Library of Medicine National Center on Minority Health and Health Disparities National Center for Research Resources Fogarty International Center Clinical Center Center for Information Technology Center for Scientific Review
NIAID Basic Research on Influenza • Viral replication and evolution • Host-virus interactions • Mechanisms and sites that stimulate immune response • Immune correlates of protection related to seasonal influenza vaccination • Modeling the dynamics of influenza transmission in large human populations • Sequence analysis of the 1918 pandemic virus and its impact on human immune response
NIAID Influenza Reagent Repository • Managed by BEI Resources • Makes reagents available to all registered researchers (including international) at no charge (shipping and handling fees only) • Influenza reagents currently available: • Purified H and N proteins • Poly and monoclonal antibodies • Influenza virus isolates • Peptide arrays designed for epitope mapping • Antiserum including human serum from H5 vaccinees Register at: www.beiresources.gov
H5 Influenza Plans Underway in SE Asia • Increase training for investigators in SE Asia in areas related to clinical research and data management • Support seroprevalence H5N1 studies in China and Vietnam through NIAID’s CIPRA program and in collaboration with AFRIMS. • Develop research studies to examine cross-reactivity of H5N1 strains and molecular characterization of strains. • Funding in FY06: $18 Million.