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Effects of CRHr1 Antagonist on AVP, GHRH, and SRIF mRNA Expression in Restraint Stress Models

This study investigates the impact of CRHr1 antagonist treatment on the mRNA expression levels of vasopressin (AVP), growth hormone-releasing hormone (GHRH), and somatostatin (SRIF) in the paraventricular nucleus (PVN) under restraint conditions. Utilizing various treatment and control groups, we analyze how restraint stress influences neuropeptide expression, providing insights into the neuroendocrine response and potential therapeutic targets for stress-related disorders.

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Effects of CRHr1 Antagonist on AVP, GHRH, and SRIF mRNA Expression in Restraint Stress Models

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  1. Handled Vehicle CRHr1 antagonist Control AVP AVP AVP Restraint AVP AVP AVP PVN

  2. AVP mRNA Expression in PVN 75 Control * Restraint * 50 Mean O.D. 25 0 Handled Vehicle CRHr1 antagonist Treatment

  3. Handled Vehicle Control CRHr1 antagonist CRH CRH CRH Restraint CRH CRH CRH PVN

  4. CRH mRNA Expression in PVN 75 Control * Restraint * * 50 Mean O.D. 25 0 Handled Vehicle CRHr1antagonist Treatment

  5. Handled Vehicle Control CRHr1 antagonist GHRH GHRH GHRH Restraint GHRH GHRH GHRH DMH-VMH&ARC

  6. Hypothalamic GHRH mRNA Expression 150 DMH, VMH & Arc Control GHRH Restraint GHRH 100 * * Mean O.D. 50 0 Handled Vehicle CRHr1 antagonist Treatment Group

  7. Control Handled Vehicle CRHr1 antagonist SRIF SRIF SRIF Restraint SRIF SRIF SRIF DMH-VMH& ARC

  8. Hypothalamic SRIF mRNA Expression 500 DMH, VMH & Arc * Control 400 Restraint * 300 Mean O.D. 200 100 0 Handled Vehicle CRHr1 antagonist Treatment

  9. Handled Vehicle CRHr1 antagonist GHRH GHRH GHRH Control GHRH GHRH GHRH Restraint SRIF SRIF SRIF Control SRIF SRIF SRIF Restraint DMH-VMH& ARC

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