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Long-Term Complications and Mortality in Young-Onset Diabetes

Featured Article :. Long-Term Complications and Mortality in Young-Onset Diabetes Type 2 diabetes is more hazardous and lethal than type 1 diabetes.

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Long-Term Complications and Mortality in Young-Onset Diabetes

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  1. Featured Article: Long-Term Complications and Mortality in Young-Onset Diabetes Type 2 diabetes is more hazardous and lethal than type 1 diabetes Maria I. Constantino, BInfoTech, Lynda Molyneaux, R.N., Frankziska Limacher-Gisler, MClinTPrac, Abdulghani Al-Saeed, M.D., Connie Luo, R.N., Ted Wu, M.D., P.H.D., Stephen M. Twigg, M.D., P.H.D., Dennis K. Yue, M.D., P.H.D., Jencia Wong, M.D., P.H.D. Diabetes Care Volume 36: 3863-3869 December, 2013

  2. STUDY OBJECTIVE • To evaluate long-term clinical outcomes and survival in young-onset type 2 diabetes (T2DM) compared with type 1 diabetes (T1DM) with a similar age of onset Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  3. STUDY DESIGN AND METHODS • Records from the Royal Prince Alfred Hospital Diabetes Clinical Database were matched with the Australian National Death Index • Mortality outcomes for all subjects until June 2011 were established • Clinical and mortality outcomes in 354 patients with T2DM, age of onset between 15 and 30 years (T2DM15–30), were compared with T1DM • Primary comparison was with 470 patients with T1DM with a similar age of onset (T1DM15–30) to minimize the confounding effect of age on outcome Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  4. RESULTS • Median observation period was 21.4 (interquartile range 14–30.7) and 23.4 • (15.7–32.4) years for the T2DM and T1DM cohorts, respectively • 71 of 824 patients (8.6%) died • A significant mortality excess was noted in T2DM15–30 with an increased hazard for death Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  5. RESULTS • Death for T2DM15–30 occurred after a significantly shorter disease duration and at a relatively young age • There were more cardiovascular deaths in T2DM15–30 • Albuminuria and less favorable cardiovascular risk factors were greater in T2DM15–30 • Neuropathy scores and macrovascular complications were also increased in T2DM15–30 Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  6. Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  7. Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  8. CONCLUSIONS • Compared with T1DM, young-onset T2DM is the more lethal phenotype of diabetes and is associated with: • Greater mortality • More diabetes complications • Unfavorable cardiovascular disease risk factors Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  9. Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

  10. Constantino M. I. et al. Diabetes Care 2013;36:3863-3869

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