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What you should know from today’s lecture

What you should know from today’s lecture. The process of DNA replication The cell cycle Eukaryotic mitosis and cell division Inhibitors of replication, mitosis, and cell division. The Central Dogma of Molecular Biology. REPLICATION. The importance of DNA replication.

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What you should know from today’s lecture

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  1. What you should know from today’s lecture • The process of DNA replication • The cell cycle • Eukaryotic mitosis and cell division • Inhibitors of replication, mitosis, and cell division

  2. The Central Dogma of Molecular Biology REPLICATION

  3. The importance of DNA replication • The basis of asexual reproduction • The basis of inheritance and fidelity of trait transmission • Errors in replication lead to mutations that produce variation upon which evolution depends • Target for anti-cancer therapy

  4. What is required for DNA replication? • dATP, dGTP, dCTP, TTP • DNA polymerase • Template

  5. Mechanism of DNA replication, part 1 Template-dependent Semiconservative Antiparallel Complementary

  6. Mechanism of DNA replication, part 2 Template-dependent Semiconservative Antiparallel Complementary

  7. Prokaryotic binary fission(cell division)

  8. Eukaryotic cell cycle (cell division) Most adult human body cells are in G1 replication Growth of multicellular organisms Reproduction of unicellular organisms

  9. Eukaryotic chromosomes replication karyotype

  10. Mitosis

  11. The results of mitosis • Orderly partitioning of chromosomes into two daughter cells • Daughter cells are identical to the parent cells in chromosome number • Any eukaryotic cell can undergo mitosis and cell division

  12. Inhibitors of replication, mitosis, and cell division • Inhibitors kill cells which are trying to divide • Inhibitors of DNA replication: ionizing radiation (g-rays), AZT • Inhibitors of mitosis and cell division: taxol, vincristine • Adult human body cells affected by radiation or chemotherapy

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