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Institute of Tropical Medicine Antwerp

Institute of Tropical Medicine Antwerp. University Hospital Brussels. Cheikh Anta Diop University of Dakar. Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission.

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Institute of Tropical Medicine Antwerp

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  1. Institute of Tropical Medicine Antwerp University Hospital Brussels Cheikh Anta DiopUniversity of Dakar Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission WimJennes, Sonja Verheyden, Julie W. Mertens, MakhtarCamara, MoussaSeydi, Tandakha N. Dieye, SouleymaneMboup, Christian Demanet, Luc Kestens

  2. How can NK cells protect against HIV-1 infection? Alloresponse: Natural killer cellskill partner HIV-1 infected CD4+ T-cells Autoresponse: Natural killer cellskillfounder HIV-1 infected CD4+ T-cells

  3. KIR/HLA typing in HIV-1 transmitting and non-transmitting married couples from Dakar, Senegal Autoresponse NK cellprotectionduetoactivating KIR and missing ligandcombinations Alloresponse

  4. KIR/HLA mismatched stem cell transplants cure leukemia Velardi et al, Curr Opin Immunol 2008; Moretta et al, Immunology Reviews 2008

  5. KIR/HLA typing in HIV-1 transmitting and non-transmitting married couples from Dakar, Senegal Autoresponse NK cellprotectionduetoactivating KIR and missing ligandcombinations Alloresponse NK cellprotectionduetomissing selfalloreactiveKIR/HLAcombinations

  6. Summary and implications • Summary • Lack of HIV-1 transmission in African couples is associated with- NK cell activating KIR/HLA genotypesin the recipient partner- KIR/HLA missing self combinations between partners • KIR/HLA missing self combinations correlate with alloreactiveNK cell killing of HIV-1 patient-derived CD4+ T cells in vitro • Implications • NK cellscouldbe important in protectionagainst HIV-1 infectionandmaybesuitable targets forfuturepreventivetherapies • KIR/HLA mismatched stem cell transplants: revolution in leukemiaCan KIR/HLA mismatches be exploited in HIV prevention and cure?

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