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Immune Response Characterization in PBMCs: HCV Core and T Cell Activation Study

DESCRIPTION

This study evaluates the immune response of peripheral blood mononuclear cells (PBMCs) in the context of hepatitis C virus (HCV) infection. It utilizes specific fluorescent markers for HCV core protein, CD4, and CD8 T cell subsets to measure cell counts and activation status. The analysis reveals significant activation and distribution patterns, with percentages noted for various immune responses. Supplementary figures provide detailed insights into the experimental setup and findings, highlighting the complexity of T cell interactions in response to HCV.

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Immune Response Characterization in PBMCs: HCV Core and T Cell Activation Study

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Presentation Transcript

  1. PBMCs 1.8% 90% FS count count SS control ab-FITC A. HCVcore-FITC CD8-ECD CD8-PE CD4-PE CD4 CD8 HCVcore-FITC HCVcore-FITC HCVcore-FITC CD4-PE M 49.6% K 31.7% K M M K HCVcore-FITC 99.8% 99.7% count count 48% 65.4% B. HCVcore-FITC HCVcore-FITC IHLs 62.6% 3.22% count count FS C. HCVcore-FITC control ab-FITC SS CD8 CD4 23.7% D E 96.2% 90% 19.2% E D E Suppl.Fig.1 count count 39.7% 43.1% D. HCVcore-FITC HCVcore-FITC

  2. t.p.inc. t.p.inc. C. A. Suppl.Fig. 2 t.p.inc B.

  3. t.p.inc. t.p.inc. C. A. D. t.p.inc. t.p.inc. B. Suppl.Fig. 3

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