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Protein Structure

Protein Structure. Biology/Chemistry of Protein Structure. Primary Secondary Tertiary Quaternary. Assembly Folding Packing Interaction. S T R U C T U R E. P R O C E S S. Primary Structure - Sequence. FOLDING. Basic Secondary structure. α -helix. β -sheet.

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Protein Structure

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  1. Protein Structure

  2. Biology/Chemistry of Protein Structure Primary Secondary Tertiary Quaternary Assembly Folding Packing Interaction S T R U C T U R E P R O C E S S

  3. Primary Structure - Sequence

  4. FOLDING

  5. Basic Secondary structure α-helix β-sheet Secondary structures, α-helix and β-sheet, have regular hydrogen-bonding patterns.

  6. 1’ > 2’ > 3’ > 4’ > … Tertiary structure Quaternary structure

  7. X - Ray X-ray Diffraction Pattern for a Protein

  8. X-Ray

  9. NMR – there is no right answer

  10. THE database of experimentally-derived structures of proteins, nucleic acids, and complexes • Access to structural information • Visualization • Analysis

  11. PDB Growth and Content Macromolecules: Proteins Nucleic acids Carbohydrates Protein-nucleic acid complexes Protein-carbohydrate complexes Experimental Methods: X-Ray Crystallography NMR more…

  12. PDB Homepage

  13. An Example – 2ARA

  14. Search Methods

  15. Advanced Search

  16. Sequence Search

  17. Example Results

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