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Chronic immune activation Inflammatory response

Cytokine storm in Leishmania /HIV-1 co-infected patients can be caused by LPS and Leishmania infection. HIV-1 / AIDS. Visceral leishmaniasis. 600,000 people infected ( Brazil ). Immunodeficiency. Parasite-specific immunosuppression. 3,500 anual/cases ( Brazil ).

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Chronic immune activation Inflammatory response

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  1. Cytokine storm in Leishmania/HIV-1 co-infected patients can be caused by LPS and Leishmania infection HIV-1/AIDS Visceral leishmaniasis 600,000 peopleinfected (Brazil) Immunodeficiency Parasite-specificimmunosuppression 3,500 anual/cases (Brazil) Chronicimmuneactivation Inflammatoryresponse Immunoactivation Inflammatoryresponse Brenchleyet al. 2006 LPS Santos-Oliveira et al. 2011 Aim: investigate whether LPS from microbial translocation is implicated in the pathogenesis of this co-infection

  2. Under HAART Which factors contribute to cellular activation and cytokine storm in co-infected patients?

  3. LPS plays an important role in the immunopathogenesis of visceral leishmaniasis-HIV-1 co-infection, acting as a co-factor to enhance the cellular activation and inflammatory cytokine response. Conclusions Acknowledgements Dr. Carmem Giacoia-Gripp, Eduardo Regis, Dr. Mariza Morgado and Dr. Alda Da-Cruz – IOC, Fiocruz Dr. Manoel Oliveira-Neto, Dr. Beatriz Grinzstejn – IPEC, Fiocruz Dr. Valdir Amato, Dr. Hiro Goto, Dr. José Angelo Lindoso - USP Dr. Jorge Guerra – FMT Dr. Priscilla Alexandrino-de-Oliveira – UFMS Brazilian Ministry of Health - PN/DST-AIDS

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