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Associations of IL10 Polymorphisms and Helminth Infections with Wheeze in Brazilian Urban Population

This study explores the co-associations of IL10 polymorphisms, IL-10 production, and helminth infections with wheeze in an urban tropical population in Brazil. It includes comprehensive tables detailing the relationships between various IL10 genetic variants and exposure to infections such as A. lumbricoides and T. trichuris, as well as their effects on IgE and IgG4 responses. The findings enhance our understanding of the genetic and immunological factors influencing allergic conditions and respiratory health in tropical environments.

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Associations of IL10 Polymorphisms and Helminth Infections with Wheeze in Brazilian Urban Population

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  1. Supplemental material: Co-associations between IL10 polymorphisms, IL-10 production, helminth infection and wheeze in an urban, tropical population in Brazil Table 1: IL10 genetic variants and IL-10 production Table 2: IL10 genetic variants and A. lumbricoideschronic infection

  2. Table 3: IL10 genetic variants and T. trichurischronic infection Table 4: IL10 genetic variants and T. trichuriscurrent infection

  3. Table 5: IL10 genetic variants and IgE anti-A. lumbricoides Table 6: IL10 genetic variants and IgG4 anti-A. lumbricoides

  4. Table 7: IL10 genetic variants and helminth Co-infection Table 8: IL10 genetic variants and skin prick test to B. germanica

  5. Table 9: IL10 genetic variants and skin prick test to P. americana Table 10: IL10 genetic variants and sIgE anti-D. pteronyssinus

  6. Table 11: IL10 genetic variants and sIgE anti-B. germanica Table 12: IL10 genetic variants and Total IgE

  7. Table 13: IL10 genetic variants and atopic wheeze CHR:chromossome; BP: base pairs; A1: Allele 1; MAF:minorallelefrequency; EMP1: pvalueconsideringadaptativepermutationsusingadditive(ADD) ordominant (DOM) model.

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