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AAN –Toronto, April 11, 2010

AAN –Toronto, April 11, 2010. Development of a harmonized protocol for hippocampal tracing An EADC-ADNI joint effort EARLY RESULTS. EARLY RESULTS. Protocols’ features extraction Features modeling & computations Discussion. PROTOCOLS’ FEATURES EXTRACTION.

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AAN –Toronto, April 11, 2010

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  1. AAN –Toronto, April 11, 2010 Development of a harmonized protocol for hippocampal tracing An EADC-ADNI joint effortEARLY RESULTS

  2. EARLY RESULTS Protocols’ features extraction Features modeling & computations Discussion

  3. PROTOCOLS’ FEATURES EXTRACTION B Bartzokis G, et al. Psychiatry Res 1998;82:11-24 C Convit A, et al. Neurobiol Aging 1997;18:131-8 H Haller JW, et al. Radiology 1997;202:504-10 J Jack CR Jr. Epilepsia 1994;35 - Suppl 6:S21-9 K Killiany RJ, et al. Arch Neurol 1993;50:949-54 L Lehéricy S, et al. Am J Neuroradiol 1994;15:929-37 M Malykhin NV, et al. Psychiatry Res 2007;155:155-65 Pa Pantel J, et al. Hippocampus 2000;10:752-8 Pr Pruessner JC, et al. Cereb Cortex 2000;10:433-42 S Soininen HS, et al. Neurology 1994;44:1660-8

  4. PROTOCOLS’ FEATURES EXTRACTION http://www.hippocampal-protocol.net

  5. PROTOCOLS’ FEATURES EXTRACTION Harmonized language Reduction of redundancy Tracing units and subunits

  6. PROTOCOLS’ FEATURES EXTRACTION Most anterior slice No longer an issue thanks to software for 3D navigation

  7. PROTOCOLS’ FEATURES EXTRACTION Plane of tracing Axis of hippocampus AC-PC B. Bartzokis et al 1998 C. Convit et al 1997 J. Jack 1994 L. Lehéricy et al 1994 S. Soininen H et al 1994 H. Haller-Csernansky et al 1997 K. Killiany et al 1993 M. Malykhin et al2007 Pa. Pantel et al2000 Pr. Pruessner et al2000

  8. PROTOCOLS’ FEATURES EXTRACTION Most posterior slice

  9. A. Level where the inferior (1) and superior (2) colliculi are jointly visualized [B] B. Slice where the crus of fornix is visible in full profile (3) [C, K, L] C. Slice where the crura of fornices on both sides are seen in full profile (4, 5) [J, S] D. Slice where an ovoid mass of gray matter (6) appears inferomedially to the trigone of the lateral ventricle (posterior to anterior) [H, M, Pa, Pr]

  10. PROTOCOLS’ FEATURES EXTRACTION Alveus Yellow = Alveus

  11. PROTOCOLS’ FEATURES EXTRACTION Fimbria Yellow = Fimbria

  12. PROTOCOLS’ FEATURES EXTRACTION Upper border

  13. PROTOCOLS’ FEATURES EXTRACTION Medial border Vertical line [C] 45° line [Pr] Line with same inclination WM [K, L, M] Horizontal line [B, H, J] Morphological details [Pa, S]

  14. EARLY RESULTS Protocols’ features extraction Features computations & modeling Discussion

  15. MODELING & COMPUTATIONS

  16. Modeling by Simon Duchesne and Nicolas RobitailleUniversité Laval and Centre de Recherche Université Laval – Robert GiffardQuebec City, Canada

  17. MODELING & COMPUTATIONS

  18. MODELING & COMPUTATIONS B C K L S J Pr M Pa H

  19. DISCUSSION Features operationalization: 4 tracing units, and subunits Preliminary info on contribution of units to total hippo volume 3D models may help Delphi panel for developing harmonized protocol Available: draft paper, and online material http://www.hippocampal-protocol.net

  20. April 14: Poster 24 PO3: Ageing and dementia imaging - other

  21. ACKNOWLEDGEMENTS Lilly International Wyeth International

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