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This study performed whole transcriptome profiling and a bioactive small molecule screen on TNBC cells with acquired resistance to HSP90i to determine the molecular basis of resistance and potential therapeutic strategies to overcome it.
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IF: 3.288 (2016) 24/01/2019 Whole transcriptome profiling and a bioactive small molecule screen were performed on TNBC cells with acquired resistance to HSP90i to identify the molecular basis of their resistance and potential therapeutic approaches to overcome it.
IF: 22.844 (2019)5y IF: 27.072 IF: 22.844 (2019)5y IF: 27.072 4 citations 14/05/2018
Razavi et al. identify mutations in the • MAPK pathway and the estrogen • receptor transcriptional program in 22% • of hormone receptor-positive breast • cancers after hormone therapy. These • mutations are mutually exclusive with • ESR1 mutations and correlate with a • shorter response duration to subsequent • hormone therapies. • Prospective sequencing of 1501 HR+ breast cancers in the clinical settin • MAPK and TF alterations were present in 22% of 692 HR+ post-endocrine therapy tumors • MAPK and TF alterations were mutually exclusive with ESR1 mutations • MAPK and TF alterations were associated with shorter response to endocrine therapies Aim: perform a large clinico-genomic analysis to identify additional genomic alterations that might mediate resistance to hormonal therapy and provide a rationale for the development of therapeutic approaches to overcome resistance.
IF: 22.844 (2019)5y IF: 27.072 14/01/2019 1 citations
Ronen et al. show that the cellular plasticity of cancer cells undergoing EMT can be exploited to force transdifferentiation of breast cancer cells into post-mitotic and functional adipocytes, leading to the repression of primary tumor invasion and metastasis formation. • Highlights • EMT-derivedbreastcancercells can differentiateintopostmitoticadipocytes • Adipogenesisdisconnectscancercellsfromaninvasive and oncogenicphenotype • EMT/MET transcriptionfactors and TGF-b signalingregulatecanceradipogenesis • Adipogenesis-inducingdrugcombinationsrepressmetastasis in preclinicalmodels • …that cancer cell plasticity is necessary for cancer dissemination but can be directly targeted and inhibited by a trans-differentiation approach, such as forced adipogenesis