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Pediatrics Oversight Committee CTSA Informal Introductions

Pediatrics Oversight Committee CTSA Informal Introductions. Bethesda, Maryland June 23, 2008.

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Pediatrics Oversight Committee CTSA Informal Introductions

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  1. Pediatrics Oversight Committee CTSA Informal Introductions Bethesda, Maryland June 23, 2008

  2. Columbia University Medical Center(Schools of Medicine, Public Health, Dental and Nursing)Facilities: 1135 bedsPediatrics: Children’s Hospital of New York with 200 bedsTraining: Full range of pediatric specialties with 60 residents, 63 fellows and 155 medical student rotating annuallyCTSA funding/year: K12 Program—2/8 Pilot Grant Award—2 /8 MS/POR—2/10 Irving Fellow—1 Irving Scholar—1 Imaging Pilot Award—1 Dedicated Research Staff—4

  3. Goals: Training, interdisciplinary collaboration, Biostatistics and IT, Community based research Current Barriers: Insufficient trained personnel, shortage of statistical support, communications across multiple schools and departments, too few patients in particular areas Potential Solutions: Standardized training and certification of research staff Research Nurse/Coordinator—3 (ER, PICU, NICU) Multi-CTSA collaboration (NYC CTSAs) Expansion of Staff in Biostatistics and IT for courses and consultation Primary and Specialty Care Collaboration

  4. Duke University Health System/Duke Translational Medicine Institute CTSA PI: Robert M. Califf MD Chair of Pediatrics: Joseph W. St. Geme III MD Voting member: Jennifer S. Li MD MHS Facilities: 3 Hospitals with 1498 total/181 pediatric bed capacity; home care and hospice services; primary and specialty care clinics in communities throughout the region Pediatric department centralized at Duke Children's Hospital and Health Center, 158 faculty members, 19 comprehensive specialties Training:73 residents, 55 subspecialty fellows, 101 students/yr on rotation; institutional and departmental K12 awards, T32 awards in the department and in pediatric cardiology, neonatology, A/I, heme-onc, rheumatology Research: 293 active protocols, 10 NIH sponsored pediatric networks, data coordinating center for 24 pediatric multi-center trials •Components: Duke Clinical Research Institute, Neonatal Perinatal Research Institute, Pediatric Site-Based Research Unit, Pediatric Genetics and Genomics Research Center. Pediatric Vaccine Unit, Pediatric Cell Therapy Unit, Quantitative Sciences, Community Research, Pediatric DCRU (phase 1 unit) 

  5. Goals: “To enhance the health of children by fostering therapeutic discovery through collaborative translational and clinical research” •Expand the therapeutic breadth of Pediatric Phase 1 studies •Expand Community component •Develop Neurodevelopmental Outcomes Research Unit •Develop targeted cell therapies for inherited metabolic disorders, brain injuries, and type I diabetes •Expand FDA-DCRI collaboration for pediatric drug trial analyses Current Barriers: 1) achieving the proper balance between specific pediatric needs and integration of research within the overall institutional effort, 2) ensuring that efforts in health services research are complementary to the operations of the health system, 3) recruitment and retention of faculty (too few in the pipeline), 4) delays to intellectual property issues and contracting 5) $$$ Potential Solutions: develop academic and industry partnerships; coordinate local and intra-CTSA research programs; collaborative informatics, terminology, and operations

  6. Mayo Clinic FacilitiesMayo Eugenio Litta Children’s Hospital90 beds (16 NICU, 30 PICU, 44 general care)Mayo Clinic T. Denny Sanford Pediatric Centercomprehensive, multispecialty pediatric clinicClinical Research Unit – inpatient, outpatient, & mobile units serving adults & childrenTraining programsPhD, Masters Degree, & Certificate programs ResearchBasic, translational, & clinical research, with emphasis on cancer, aging, behavioral & developmental biology, immunology, CV & GI conditions, vaccinology & infectious diseases Mayo Eugenio Litta Children’s Hospital Mayo Clinic T. Denny Sanford Pediatric Center W. Charles Huskins, MD, MSc Robert M.Jacobson, MD

  7. Mayo Clinic GoalsExpand ranks of experienced translational investigatorsEnhance multidisciplinary translational research, particularly for musculoskeletal, gastrointestinal, & neurologic conditionsCurrentbarriers Small but growing cadre of pediatric investigators Small but growing community with limited diversity Community engagement programs just being initiatedPotentialsolutionsEnhance research education & training opportunitiesCollaborate in multicenter studies, particularly those involving conditions affecting children and adultsExpand community engagement programs

  8. Oregon Health & Science University (OHSU)Facilities: Doernbecher Children’s Hospital:151 beds OHSU Hospital: 373 beds. Also VA, Shriners Pediatric Department located at Doernbecher Children’s Hospital on main campus of OHSU connected to OHSU Hospital; 70 facultyTraining: Nearly full range of pediatric specialties with fellowship training-24 fellows currently in training. Medical student training: 190 students per year on rotation and electiveCTSA Research: CTRC: 22 pediatric protocols from 10 PI’s; many additional pediatric studies utilizing CTSA related services

  9. Goals – Education & Training: Train a cadre of early career pediatric C/T researchersTranslational research in metabolic disease/nutrition/genetics, endocrinology, oncology, renal; expand into cardiology, infectious disease, neuroscience. Expand on strong base in community researchCurrent Barriers : Few senior mentors in C/T research, relatively small patient base in some areas, PI’s too busy trying to renew basic science grants to consider developing new C/T research collaborationsPotential Solutions : enlist assistance of senior mentors from outside department, collaborate with other institutions in research subject recruitment, form teams of basic scientists and C/T researchers especially with internal funding opportunities to incentivize new C/T research collaborations

  10. Rockefeller University Hospital, New York, NYFirst free-standing clinical research center, established 1901Inpatient unit with 20 bed capacity + outpatient unit, both devoted solely to clinical research protocolsOrganized by individual labs rather than academic departmentsTraining: CTSA Clinical Scholars Program grants Master’s in Clinical and Translational Science (16 scholars as of July 1, 2008)Research: 99 active protocols in the areas of HIV, dermatology, addiction, obesity, oncology, hematology, and immunology11 protocols include volunteers under the age of 18None of the active protocols are focused exclusively on children,although RU has a history of pediatric research in the past. Sandhya Vasan, M.D Voting Member

  11. Goals: To expand the scope of current pediatric researchTo continue to improve training for new translational investigators Current Barriers:Small research hospital with no pediatric departmentPotential Solutions: Recruitment of new pediatric faculty (e.g., Jean-Laurent Casanova) Collaborative studies with other CTSA centersActive tracking and feedback on K12 Clinical Scholars Program

  12. University of California, Davis Medical Center • One of 5 UC Schools of Medicine • Location: Sacramento State Capital; Davis campus 20 miles w. • Facilities: 600 bed acute care hospital, level I Peds Trauma • Children’s Hospital (Hospital within hosp)120 beds • Dept Pediatrics integral part of Med Center: 90 faculty • Other academic Depts in support (Radiol, Anesth, Surg, etc) • Shriners Hospital (multidisciplinary) on campus and active collaborator • Training: medical students, Pediatric residency program, residents from FP, • Travis AFBand 5 fellowship programs • Research: • Research labs and clin programs >100 active protocols • some clin themes incl Frag X, Ca, Autism, Ethics, Diabetes, Vaccines • Wet labs with themes Obesity, Asthma, Renal, Nutrition, Genetics • Stem Cell/Cancer, Infect Dis. • UCD campus collaborators: Primate Ctr, Vet and Agric Schools, Ctr Health and Tech (Telehealth), MIND Inst, and others Anthony Philipps, M.D.

  13. Goals • Improvement in “brokering” relationships between clinicians, “bench” scientists and industry and technology • Acceleration of multicenter and local clinical trials • Training of competent clinical research scientists for the future • Current Barriers • Local and regional competition for, “town and gown” political problems • Fiscal crises: federal, state and local county • Faculty time and effort, P and T committee issues • Space limitations: labs, offices • Administrative barriers and red tape- internal and UC-wide: • Contracts, liability, Intellectual property rights • IRB • Solutions • Partnering (Shriners. LLNL examples), web based dialogue both internal and external • Local Symposia as showcase and forum for discussion and exchange of ideas • Use of K30 program and K12 grants (2 currently In Pediatrics) coupled with CTSA funds to develop new clinical investigators, funds for Peds Clinical coordinator

  14. UCSF CTSI Pediatric Clinical Research Center UCSF, Children’s Hosp of Oakland, Kaiser Oakland, SFGH, Mount Zion PCRC Advisory Committee reviews all protocols Access through CTSA to Bioinformatics, Statistics, “SOS” pilot funds UCSF Independent PCRC for 30 years prior to CTSA, pioneer in pediatric HIV Currently a site of the UCSF CTSI CRC 5-bed inpatient unit with lead-lined room Outpatient unit and infusion center ICU research nursing team covering: Neonatal, Cardiac and Pediatric ICUs, Transitional and Well Baby nurseries, L&D, OR, Imaging & Radiology Specimen Processing Lab, shipping, EBV lines Neurodevelopmental psychologist, full time Nutritionist, DEXA, body composition & exercise testing Pediatric Research Pharmacy Poster printer

  15. UCSF CTSI Pediatric Program Goals and Challenges Integrate Research into the design of the new UCSF Children’s Hospital, currently planned to open 2012-2014. Increase the pipeline of pediatric translational investigators. Broaden the scope of research conducted in the PCRC. Make funds and research coordinator support available for starting projects that will lead to competitive funding applications. Participate in more multi-institutional studies, we hope by taking advantage of CTSA infrastructure. J Puck, June 18, 2008

  16. Children’s Hospital of PhiladelphiaUniversity of Pennsylvania • 430 bed free-standing hospital (CHOP) affiliated with University of Pennsylvania • Developed by merging 2 GCRC’s • $129,708,000 of extramural funding in FY 07 • 180 current pediatric CTSA protocols • 21 pediatric divisions / departments

  17. Goals: Translational therapeutics; Bridging the pediatrics / adult divide; Education and investment in human capital • Barriers: Transforming culture; Uncertain funding climate; Lack of support for pilot studies • Solutions: Joint roles; Charge-back mechanism & institutional support; Pilot grants • Goals for POC: Establishing strong pediatric networks for research and advocacy

  18. Research:-76 active pediatric protocols, from 17 sub-specialties (PCTRC) - 13 active pediatric protocols, from 5 sub-specialties (PBRN)Training: Unified Fellows Course; 3 year program tailored to the professional development of fellows in the Department of Pediatrics.The overall goal is to assist fellows in making a successful transition from fellowship to early faculty positions as physician-scientists, clinical researchers and academic educators in their subspecialties. • University of Pittsburgh Clinical and Translational Science Institute • Participant and Clinical Interactions Resources Core (PCIR) • Pediatric Clinical and Translational Research Center (PCTRC) • Pediatric PittNet (Practice Based Research Network)

  19. Goals: -Reduce barriers to investigators - Expand practice based researchCurrent Barriers:- Regulatory, IRB issues- Parental concern about participation of children in clinical researchPotential Solutions:- S. Arslanian (Dir. PCTRC), D. Perlmutter (Dept. Chair) and C. Ryan (IRB Chair) formed Advisory Committee to address local barriers- Participation in POC to address IRB barriers and facilitate pediatric research- A. Hoberman joined PCTRC, Advisory Committee and POC to provide expertise in practice based clinical research. Developed multicenter survey to assess factors that influence parents decisions to consent to research • University of Pittsburgh Clinical and Translational Science Institute • Participant and Clinical Interactions Resources Core (PCIR) • Pediatric Clinical and Translational Research Center (PCTRC) • Pediatric PittNet (Practice Based Research Network)

  20. Department of Pediatrics, Rochester NYClinical Facilities: - 2 hospitals, all pediatric subspecialty care centralized- 2 large primary care practices (40% of city children) - Incredible town-gown relationshipResearch- Major health services research program (50% of total)- Large programs in ID, neonatology, renal, neurology, heme-onc, others - Altogether > 100 protocolsTeaching- 40 residents, 100 students, community pediatrics

  21. Department of Pediatrics, Rochester NYCurrent CTSA Activities- Pediatric researchers involved in many of the 11 functions. - Pediatric faculty have leadership positions in: -Administrative Core -Community Engagement (Co-PI on PBRN, NIH suppl.) -Research Education and Career Development -Upstate Consortium Goals- More funding from CTSA programs- Improved centralized research office for studies (fieldwork)Barriers- IRB, IT for EMR for PBRN, Communications, Funding Solutions- Work collaboratively within CTSI

  22. Goals • Advance basic, translational, and clinical science for children • Barriers • Competing priorities, awareness, researcher “pipeline”, absence of industry partners, ethical concerns, small sample size • Solutions • Skills development programs, pediatric research infrastructure, leveraging resources, collaboration across NIH Institutes, CTSAs

  23. Facilities: Two outpatient units 240 inpatient beds; Day Hospital Pharmacy/processing laboratory SQUID,DEXA,Nutrition Cart Diverse patient population, Sub-specialty programs, 5 fellowships and 75 residents T32 and K training programs University affiliations: UCSF, UC Berkeley, UC Davis Extensive genomic, biochemistry, cell biology laboratory resources Focus on translational research and training School based programs Research Seven “Centers of Excellence” Ranked #5 Nationally in NIH funds in 2007 400 clinical protocols, 40 in CRC:hemoglobinopathies, oncology, diabetes, obesity, asthma,nutrition, genomics, birth defects, cystic fibrosis neurodevelopment, cord blood cardiovascular, alcohol and substance abuse Active participant and leader in NIH clinical trail networks and industry studies Pediatric and adult studies Community oriented programs Minority internships Oakland Children’s Hospital (UCSF)

  24. Goals Increase translational research projects Support development of junior faculty Increase training activities Increase collaborations with other CTSA programs Expand community engagement programs Expand minority recruitment activities Increase participation in NIH multicenter trials Continue SEPA programs Develop community based programs Barriers insufficient funding to support staff, junior investigators, ancillaries, or develop new programs Can’t accept new protocols Can’t support junior staff projects NIH flat budget Future projections Potential Solutions Funding from philanthropy, industry, or medical center Funding from NIH, foundations, or business community Oakland Children’s Hospital (UCSF)

  25. Case Western Reserve University Pediatrics in the Clinical and Translational Science Collaborative Three hospitals with Pediatric Units (one a top-5 hospital) each has training program and fellowships in toto in 14 subspecialties, famous in neonatology and pulmonary Medical students rotate at all three hospital systems in Pediatrics Most popular specialty chosen by graduating seniors last year. Department with >$30M in external research support

  26. CTSA Participation Effective competitor for K12 slots at all the institutions, plus more than 12 K awards outside CTSA - participate in “K community” Many K awardees cross disciplines Training component emphasizes K to R transition. Major CRU user at the site of largest inpatient usage – CF, sleep programs, PPRU site – One CRU located in Children’s Hospital CTSC plans to upgrade the Pediatric Practice Based Research Network as a new leader is recruited – was active under former leader

  27. Clinical and Translational Research Program for Pediatrics (CTRPP)Atlanta, Georgia Emory University - Dept of Pediatrics Morehouse School of Medicine (MSM) – Dept of Pediatrics Children’s Healthcare of Atlanta (CHOA) Georgia Institute of Technology

  28. Pediatric Clinical Interaction Sites

  29. Facilities • 452 staffed beds in three hospitals • 23 satellite locations around metro Atlanta • 5 immediate care centers • 2 primary care centers • 30 pediatric specialties • 493,00 patient visits • 227,000 unique patients • 128,000 inpatient days • 5,800 outpatient days • 34,200 surgical procedures (in-patient and out-patient) • 123,000 ED visits • 117,000 Immediate care center visits • 61,400  Primary Care Visits

  30. Research • over 700 protocols • 14 protocols using adult GCRC • Building centralized inpt/outpt research unit at Egleston • Centralized research department at CHOA • Centralized lab at Egleston supporting studies • Research pharmacist (1.0 FTE)

  31. Goals • Establish network of centrally organized pediatric clinical interaction sites, fostering integration and collaboration. • Encourage basic and clinical scientist interaction, enhancing discovery and clinical implementation, improving children's lives. • Build a robust centralized research infrastructure dedicated to pediatrics, including a dedicated Pediatric Clinical Trials Office. • Develop the Child Health Institute at MSM, incorporating research and collaborations with education, patient care, and advocacy, to build collaborative care for children with special healthcare needs. • Expand and enhance our training program in pediatric clinical and translational research and ensure researchers have the tools to become successful and independent. • Create a bidirectional process between the Clinical Interaction Sites and the Community Engagement program to disseminate pediatric clinical and translational research results

  32. Barriers • Staffing research unit/hiring of qualified research nurses • Multiple sites/geography • Multiple IRBs (Emory/CHOA/Grady) • Total research staff (IRB/grants/contracts) • Electronic data/databases • Working to integrate 2 separate research infrastructures at CHOA/Emory

  33. Solutions • Funding support from other sources • Accessing Nursing Research Alliance for qualified nurses • Sharing of resources with other programs to optimize efficiency • Community engagement

  34. Facilities: Johns Hopkins Medical Institutions and the Kennedy Krieger InstituteJohns Hopkins Childrens Center integrated within Johns Hopkins HospitalTraining: Pediatrics internships, residency, subspecialty fellowships, T32 and K12 training programsPediatric Clinical Research Unit consisting of 7 inpatient beds, outpatient clinic, procedures unit, infant lung function laboratory, mucociliary clearance laboratory, sleep laboratory Johns Hopkins Institute for Clinical and Translational Research---A CTSA program in Baltimore, MD

  35. GOAL • 1) Enhancing communication across the multiple programs in the ICTR • 2) Finding best ways to leverage research infrastructure • a. Relationships with various schools • b. Relationships with cancer center • 3) Creating an academic home for translational researchers without a single physical location • 4) Measuring output or translational research successes • 5) Identifying most productive approaches to working with other academic institutions within CTSA • CHALLENGE • Having the discipline to evaluate programs and reallocate resources • WE OFFER • 1) Basic science and clinical translational forums • 2) Translational Research Navigator Program • 3) Advanced Translation Incubator Program (ATIP) • 4) Community Engagement Office • 5) Proteomics, Genetics, and Imaging Cores • AND MUCH MORE………..

  36. University of Chicago • Facilities: 2 hospitals (Comer Children’s and LaRabida Children’s Hospitals) with 200 beds combined • Training: 54 peds-, 16 med/peds-, and 3 chief-residents; 42 accredited fellowship positions in 9 subspecialties and 2 positions in pediatric surgery • Research • Laboratory-based research with emphasis on translational applications. For example, • Sue Cohn and her work on angiogenesis in cancer • Bob Daum and his work on MRSA • Mike Moskowitz and his work on the genetic basis of congenital heart disease • John Cunningham and his work on new therapies for sickle cell disease • Therapeutic clinical trials. For example, • Participation in the Children’s Oncology Group • Ken Alexander and his work in HPV • Mike Schreiber and his work on nitrous oxygen • Health services research (ethics and outcomes) • Becky Lipton and her epidemiological work on diabetes • Alyna Chien and pay-for-performance health services research • Lainie Ross on expanding newborn screening • Resources: • New lab space to open in the Knapp Center for Biomedical Discovery • Establishment of Pediatric Clinical Trials Office (1/07) • MacLean Center for Clinical Medical Ethics with expertise in research ethics • 255 active IRB approved protocols in Dept of Pediatrics

  37. University of Chicago • Research • Goals: continue T-1 research; expand T-2 research including both community-based participatory research [CBPR] and practice-based participatory research [PBPR] • Current Barriers: unfunded mandates (our CTSA funding was cut administratively by 50%); inconsistent application of human subject protections across institutions; shortage of statistical support requiring outsourcing; need for external support for biobanking initiatives • Potential Solutions: Institutional support for pediatric clinical trials office to supplement university-wide clinical trials office; strong institutional support for community-based pilot projects and for biobanking initiatives; seeking outside funding to enrich statistical center as well as collaboration within the University (Health Studies)

  38. University of Iowa CTSA Pediatrics Key Function - 1Paired with the Genetics/Genomics Key FunctionOnly Medical School in state, 70 Bed NICU, Numerous statewide pediatric programs (Perinatal, Birth Defects, Nursing etc)Four Aims1. WIKI based interactions between pediatric faculty/staff/student (Donna D’Alessandro)2. School nurse outreach to facilitate clinical trials in the community (Ann Marie McCarthy)3. Perinatal health projects to integrate laboratory with clinical activities including NIH Neonatal Network (Jeff Murray/Ed Bell)4. Biorepository of data/samples on pediatric in/outpatient population (Jeff Murray)

  39. University of Iowa CTSA Pediatrics Key Function - 21. Goals - better internal/external communication;training of school nurses;expand existing biorepository (currently NICU only)2. Barriers - buy in for use of Wiki’s;resources for school nurse training;capacity building for biorepository3. Solutions - education, new hospital EMR implementation and work with Bioinformatic key function;partner with College of Nursing and grants for school nurses;working with genetics/genomics core, financial support from the hospital and College of Medicine to expand biorepository, partner with other CTSAs

  40. Michigan Institute of Clinical and Health Research (MICHR) • MICHR CTSA: To provide infrastructure and tangible support to develop, help secure funding, and conduct high quality clinical and translational research projects that will positively affect patient care and outcomes • Pediatric Research Program (PRP): One of 12 programs within the MICHR CTSA • Pediatric Clinical Research Committee: Consultative committee of the PRP - currently consists of 17 faculty members with different specialties across divisions with the Department of Pediatrics and divisions with a pediatric focus in other Departments or Schools

  41. Pediatric Research Program within MICHR • To develop and supportmultidisciplinary clinical and translational research teams in pediatric populations • To contribute to the clinical research educational and mentoring mission of the UM CTSA • To serve as a central point of contact for investigators who seek to conduct biological, clinical, epidemiologic, or health services research with translational potential that involves children, adolescents, and/or their families

  42. UT Southwestern Medical Center at Dallas 7 affiliated hospitals (3 pediatrics-only facilities; 2000 beds) Pediatric hospitals Children’s Medical Center Dallas (411 beds) – teaching Parkland Memorial Hospital (810 beds) – teaching Texas Scottish Rite Hospital for Children (100 beds) – teaching Children’s Medical Center Legacy (72 beds) – non-teaching Training 230 medical students per year 87 pediatric residents per year 19 pediatric residencies or fellowships Pediatric clinical and translational research Main players: Hematology-Oncology, Infectious Disease, Psychiatry, Urology Clinical research department at CMC Dallas New Department of Clinical Sciences at the University Charles Quinn, MD, MS

  43. Goals Advance the standing of clinical research at the university Improve the quality and quantity or pediatric research at the university Train investigators in clinical sciences Develop an interactive community of clinical investigators Current Barriers History and pre-eminence of basic science research Small, scattered community of clinical investigators Lack of integration between the CTSA/University and Children’s Potential Solutions KL2/K12 Clinical Research Scholars’ Program (12/39 scholars are pediatricians) Integrate the adult and pediatric research infrastructure where appropriate Increase pediatric funding opportunities Regular multi-disciplinary meetings of pediatric clinical researchers Good ideas from this meeting

  44. Seattle Children’s Hospital Research Institute (SCHRI) • Site of University of Washington CTSA pediatric program – Bonnie Ramsey, Co-PI • $31 million in research funding • Over 400,000 ft2 of research space • 190 Investigators • Growth • 80,000 ft2 under construction now • Building 2 complete in 3-5 years adding over 500,000 ft2 to the campus • Growth potential to 2 million ft2 • Successes of Pediatric Program in Year 1 of UW CTSA • Pediatrics well-integrated into leadership including PCRC, Regulatory Support, Bioethics, Informatics and Novel Methods • Center for Clinical and Translational Research established at Seattle Children’s Hospital as link between institution and CTSA • Creating common practices between Children’s and UW – CRC functions, billing guidelines, common application and IRB reciprocity • CTSA Pilot Program and Mentored Scholars Program for investigators focusing on childhood disorders launched May 2008 (institutional support from SCHRI)

  45. UW/SCHRI Partnership for CTSA Goal • Training – implement Mentored Scholars Program (4 scholars chosen) for pre-K early faculty • Research support – implement CTSA Pediatric Biomedical Informatics and Statistics core in Fall 2008; recruit senior biostatistical faculty • Implement cost sharing program for PCRC Current barriers • Delays in contract negotiations • Data management support • Inability for research support staff to move across UW affiliated institutions Potential solutions • Utilize Toyota LEAN process to optimize contract negotiations across UW CTSA institutions • Establish common training/certification of research staff across UW institutions

  46. University of Wisconsin-Madison • American Family Children’s Hospital: 60 bed facility opened August 2007 • Adult and VA hospitals on same campus (UW-Madison main campus) • Pediatric department centralized at teaching hospital • Full range of pediatric specialties • 39 pediatric residents, 15 sub-specialty fellows • Institutional and cooperative group clinical research (Children’s Oncology Group, Childhood Asthma Research and Education)

  47. Goals: • streamline IRB/CTRC review process • coordinate ICTR resources • provide more “pediatric friendly” services for participants in ICTR studies • Barriers: • still in early stages of implementing ICTR plan • some pediatric investigators lack infrastructure for efficiently conducting studies and meeting participants’ needs • Solutions: • implementation of ICTR plan is in progress • some pediatric researchers hold leadership roles within the UW-ICTR and will advocate for pediatric studies and participants

  48. Facilities: Three hospitals; Beds: 916: ; Pediatric CRCPediatric department in stand-alone children’s hospital, as part of larger academic centerTraining: Full range of pediatric specialties with fellowship training; 74 fellows; K12 mentored career developmentResearch: 26 laboratories; 52 active protocols in pediatric CRC Vanderbilt Institute for Clinical and Translational Research Monroe Carell Jr Children’s Hospital at Vanderbilt Shari Barkin, MD, MSHS Kathryn Edwards, MD

  49. Vanderbilt Institute for Clinical and Translational Research Goals: 1)Establish physical and virtual home for translational investigation; 2)Stimulate/streamline communications and remove impediments; 3)Develop a new generation of investigators; 4) Actively develop novel methodologies Current Facilitators: Pilot funds available using the “Starbrite system”; Access to “studios” for assistance in hypothesis generation, methodology; statistical considerations, and translation. Current Barriers: Lack of inpatient pediatric CRC Potential Solutions: Use of adult CRC and scatter beds in the Children’s Hospital

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