1 / 18

Ovary

Ovary. Diseases of the ovary. nonneoplastic lesions - pelvic inflammatory disease - ovarian cysts - endometriosis ovarian tumors - epithelial ( surface epithelial-stromal ) - sex cord-stromal - germ cell - germ cell sex- cord stromal. Ovarian cysts. Nonneoplastic.

horace
Télécharger la présentation

Ovary

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Ovary

  2. Diseases of the ovary • nonneoplasticlesions • - pelvicinflammatorydisease • - ovariancysts • - endometriosis • ovariantumors • - epithelial (surfaceepithelial-stromal) • - sex cord-stromal • - germ cell • - germ cell sex-cordstromal

  3. Ovarian cysts Nonneoplastic Cystic tumors epithelialtumors - cystadenoma (benign, borderline) - cystadenocarcinoma germ cell tumors - dermoid cyst • inclusion • functional • endometrioid

  4. Nonneoplasticcysts • inclusioncysts • - inclusionsofthesurfaceepithelium • - inclusionsfromfimbrialepitehlium • functionalcysts • - follicular cyst • - corpus luteum cyst • - hemorrhagic cyst • endometrioid cyst

  5. Ovarian tumors

  6. Classification of ovarian tumors • surfaceepithelial (epithelial-stromal) tumors • sex cord-stromaltumors • germ cell tumors • germ cell sex cord-stromaltumors

  7. Classificationofsurfaceepithelialtumors • according to their gross features: • - cystadenoma (cystadenocarcinoma) • - cystadenofibroma • - adenofibroma (adenocarcinofibroma) • - surfacepapilloma (surfacepapillarycarcinoma) • according to theirhistogenesis

  8. Surfaceepithelialtumors • benign • borderline • malignant • serous • - low grade • - high grade • endometrioid • clear cell • mucinous

  9. Benignepithelialtumors • canbelarge (especiallymucinoustumors – theworld´sbiggest tumor weighted 136 kilos) • symptoms and signsusuallynonspecific: • - pelvicpain • - discomfort • - anasymptomaticpelvic mass • up to 25% oftumorsbilateral

  10. Borderlinetumors • increasedepithelialproliferation • do not display invasion • usuallybehave in a benignfashion • but behaviorcanbemalignant • clinicalfeaturessimilar to thoseforbenigntumors

  11. Borderline tumor vs. carcinoma

  12. Ovarian cancer • about 30% ofallcancersofthefemalegenitaltract • incidence rates are highestin the economically advanced countries (most frequent cause ofdeathdue to gynecologicalcancer) • epithelialcarcinomasaccount for 90% of these cancers in North America andWestern Europe • in some Asian countries, including Japan,germ cell tumours account for a significant proportion (20%) ofovarian malignancies

  13. Ovariancancer Risk factors Protectivefactors increased parity oral contraceptive use surgicallyinduced: - hysterectomy - tuballigation - bilateralsalpingo-oophorectomy • age • reproductivefactors • - early menarche, latemenopause • highsocioeconomic status • - lower fertility • BRCA1/2 mutation (5-10% hereditary)

  14. Incidence and mortality Czech Republic 2006

  15. Classificationofovariancarcinomas (WHO) surfaceepithelial-stromal (98%) endometrioid (10%) carcinosarcoma low grade serous (<5%) uncertainhistogenesis high grade serous (70%) undifferentiated mucinous (3%) small cell, lung type unspecified clear cell (10%) small cell, hypercalcemic type malignantBrenner tumor squamous cell large cell neuroendocrinne urothelial arisingfromteratoma(dermoid cyst) adenoidcystic adenocarcinoma hepatoid othertypesofcarcinoma

  16. Prognosticfactors • histologic subtype • histologic grade • stage • advancedcancer: • - macroscopic absence ofresidual tumor afterprimarysurgery

  17. about 8 % ofallovariantumors composedof: granulosacells thecacells fibroblastsofstromalorigin Sertolicells Leydigcells singly or in variouscombinations Sex cord-stromaltumors granulosa cell tumor (adultorjuveniletype) thecoma fibroma fibrosarcoma Sertoli cell tumor Leydig cell tumor

  18. Germ cell tumors • different tumor typesderivedfromthe primitive germcellsoftheembryonicgonad • represents: • -about 30% ofallovariantumors (up to 95 % are maturecysticteratomas) • - about 3 % ofallovariancancers (western world) • - up to 20 % ofallovariancancers (Asia)

More Related