1 / 10

Joint Diseases 2

Joint Diseases 2. Categories of Joint Disease: ​--Traumatic (ruptured ligament/meniscus, osteochondral fracture ) ​ --Infectious (** gonococcal arthritis**) -- Degenerative (osteoarthritis) -- Rheumatic (rheumatoid arthritis, ankylosing spondylitis ). Osteoarthritis

hoshi
Télécharger la présentation

Joint Diseases 2

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Joint Diseases 2

  2. Categories of Joint Disease: • ​--Traumatic (ruptured ligament/meniscus, osteochondral fracture) • ​--Infectious (**gonococcal arthritis**) • --Degenerative (osteoarthritis) • --Rheumatic (rheumatoid arthritis, ankylosingspondylitis).

  3. Osteoarthritis • This is the most common disability in the U.S. • OA is a failure of articular cartilage with a hypertrophic response of the underlying bone​(loss of joint space, increased bone density with bone spurs).

  4. --Primary OA is a genetic/familial weakness of cartilage or bones and gait. • --Secondary OA is from an old fracture or necrosis.

  5. Rheumatoid Arthritis • Synovitis with proliferation of the synovium (“pannus”)and an inflammatory cell infiltrate. • This destroys joints and produces subluxations.

  6. RA is an autoimmune disease in which the synovial collagen is the target. • It is also partly caused by RF-antibodies that deposit in the synovium and activate complement.

  7. Juvenile Rheumatoid Arthritis is a self-limited RA preceded by fever and hepatosplenomegaly. • This is also autoimmune, but RF-antibodies are negative.

  8. Gout • Gout is often secondary to renal disease or chemotherapy (huge release of purines as​ neoplasmsare killed). • Almost all cases are an acute synovitis in the big toe M-P joint.

  9. Almost all males. • Chalkly nodules of uric acid (“tophi”) accumulate in the soft tissues and destroy bones​and ligaments.

  10. Pseudogout • Pseudogout is often caused by a familial defect in pyrophosphate metabolism. • It is caused by deposition of calcium pyrophosphate in joints. • These are cubic crystals. • Pseudogout often leads to osteoarthritis.

More Related