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AL Chemistry Group Project Topic: Metformin

Metformin is a key pharmaceutical agent used to control blood sugar levels, particularly for those suffering from type 2 diabetes in an insulin-independent manner. This project delves into metformin's structural formula, its role in lead compound discovery, and the methods for molecular modification. We detail the formulation development of metformin, available in immediate-release (500 mg, 850 mg, and 1000 mg) as well as slow-release (500 mg and 750 mg) tablets, which were introduced in 2004. Safety assessments and human trials have confirmed its efficacy and market approval.

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AL Chemistry Group Project Topic: Metformin

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  1. AL Chemistry Group ProjectTopic: Metformin 7SLam Kit Yan (13)7SLam Yin Kwai (14)

  2. Structural formula of metfomrin

  3. It can ….. • helps control blood sugar levels • Treat type 2 diabetes (insulin independent)

  4. Lead compound discovery

  5. Molecular modification

  6. Remarks: • quimolar amount of(1) and (2) dissolved in toluene • quimolar amount of hydrogen chloride is slowly added • after cooling(3) precipitates with 96% yield.

  7. Formulation development • Metformin IR (immediate release) is available in 500 mg, 850 mg, and 1000 mg tablets • Metformin SR (slow release) or XR (extended release) was introduced in 2004, in 500 mg and 750 mg

  8. Safety tests and human trials

  9. Approval for marketing

  10. Reference: • http://www.medicinenet.com/metformin/article.htm • http://www.drugs.com/metformin.html • http://en.wikipedia.org/wiki/Metformin

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