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AL Chemistry Group Project Topic: Metformin

AL Chemistry Group Project Topic: Metformin. 7SLam Kit Yan (13) 7SLam Yin Kwai (14 ). Structural formula of metfomrin. It can …. helps control blood sugar levels Treat type 2 diabetes (insulin independent). Lead compound discovery. Molecular modification. Remarks:.

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AL Chemistry Group Project Topic: Metformin

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  1. AL Chemistry Group ProjectTopic: Metformin 7SLam Kit Yan (13)7SLam Yin Kwai (14)

  2. Structural formula of metfomrin

  3. It can ….. • helps control blood sugar levels • Treat type 2 diabetes (insulin independent)

  4. Lead compound discovery

  5. Molecular modification

  6. Remarks: • quimolar amount of(1) and (2) dissolved in toluene • quimolar amount of hydrogen chloride is slowly added • after cooling(3) precipitates with 96% yield.

  7. Formulation development • Metformin IR (immediate release) is available in 500 mg, 850 mg, and 1000 mg tablets • Metformin SR (slow release) or XR (extended release) was introduced in 2004, in 500 mg and 750 mg

  8. Safety tests and human trials

  9. Approval for marketing

  10. Reference: • http://www.medicinenet.com/metformin/article.htm • http://www.drugs.com/metformin.html • http://en.wikipedia.org/wiki/Metformin

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