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Comparison of Endeavor ZES and Taxus PES in Coronary Lesions: Endeavor IV Trial Results

The Endeavor IV trial compared the Endeavor ZES and Taxus PES for single de novo coronary lesions during PCI procedures. Results at 2 years showed similar rates of MACE, target vessel failure, and stent thrombosis between the two arms. Further studies are needed to confirm the lower incidence of non-Q-wave MI observed with ZES.

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Comparison of Endeavor ZES and Taxus PES in Coronary Lesions: Endeavor IV Trial Results

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  1. ENDEAVOR IV MACE similar between the two arms Incidence of non-Q-wave MI lower in the ZES arm (p = 0.022), target vessel failure similar between the two arms (p = 0.23) Overall rates of stent thrombosis similar (p = 0.93) (p = 0.84) PES (n = 775) ZES (n = 773) Trial design: ENDEAVOR IV was a randomized trial of the Endeavor ZES vs. the Taxus PES in patients undergoing PCI for single de novo coronary lesions. Clinical outcomes were compared at 2 years. Results 20 20 15 15 % % Conclusions 10.0 9.8 10 10 • Among patients undergoing PCI for single de novo lesions, use of ZES associated with a similar incidence of MACE, target vessel failure, and stent thrombosis vs. with PES • The lower rate of non-Q-wave MI noted with ZES compared with PES needs to be corroborated by other studies 5 5 1.9 1.6 0 0 MACE Stent thrombosis Leon MB, et al. JACC Cardiovasc Interv 2009;2:1208-18

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