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Enzymes In Depth

Enzymes In Depth. With pH!. pH. Enzymes. Globular proteins Built from amino acids that have acidic and basic characteristics Amino acids have both a carboxylic acid (COOH) and amine (NH3) groups. Enzymes. R-COOH  C-COO -1 + H+1 R-NH3 +1  R-NH2 + H+1 Ionic bonds

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Enzymes In Depth

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  1. Enzymes In Depth With pH!

  2. pH

  3. Enzymes • Globular proteins • Built from amino acids that have acidic and basic characteristics • Amino acids have both a carboxylic acid (COOH) and amine (NH3) groups

  4. Enzymes • R-COOH  C-COO -1 + H+1 • R-NH3 +1  R-NH2 + H+1 • Ionic bonds • Increase solution pH can shift equilibrium

  5. Active sites have R groups • R groups help substrates attach to active site • Only works if the arrangement of R groups interact properly

  6. +/- • H = Hydrogen bonding • R = Van der Waals bonding

  7. At optimal pH • Enzyme attaches to substrate with 2 ionic bonds  • Groups allow for ionic bonding (caused by a transfer of H ion from COOH in the side chain of one amino acid to a NH2 group

  8. Acidic pH • Nothing will bother the NH3 + but the COO will want a H ion • pH (acid = more H ions; basic = more OH ions) • No ionic bond can form 

  9. Basic pH • COO- will not be affected • But NH3+ will lose a H • No ionic bond will form 

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