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Impact of EGFR Mutations on Erlotinib and Gefitinib Sensitivity in Lung Cancer

This study examines EGFR mutations' differential effects on receptor sensitivity towards erlotinib and gefitinib inhibition in lung cancer, particularly involving the meninges. The research sheds light on how gefitinib may be effective in cases refractory to erlotinib and highlights the role of EGFR mutation.

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Impact of EGFR Mutations on Erlotinib and Gefitinib Sensitivity in Lung Cancer

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  1. Figure 4 EGFR mutations and differential effects on the sensitivity of the receptor towards inhibition by erlotinib and gefitinib Choong NW et al. (2006) Gefitinib response of erlotinib-refractory lung cancer involving meninges—role of EGFR Mutation Nat Clin Pract Oncol 3: 50–57 doi:10.1038/ncponc0400

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