Raimund Ubar

1. CEBE IAB-Meeting Tallinn, September 16, 2013CEBE IAB-meetingCEBE – Centre of Excellence for “Integrated Electronic Systems and Biomedical Engineering“ Raimund Ubar

2. International Advisory Board WELCOME to Tallinn • Marta Rencz-Budapest University of Technology,Hungary • Bashir M. Al-Hashimi - University of Southampton, UK • Jürgen Bommer-Dialysezentrum Heidelberg, Germany • Bernard Courtois-CMP, France • Rainer Dorsch- Bosch, Germany • Manfred Glesner-TU Darmstadt, Germany • Ahmed Jerraya- CEA-LETI, MINATEC, France • JaakkoMalmivuo- Tampere University of Technology, Finland • UwePliquett-InstitutfürBioprozess- und AnalytischeMesstechnik, Germany

3. Program

4. Overview • General about CEBE (position in Estonia, structure, research fields, new project activities, mission) • Slogan of CEBE – HEALTH2 • Two types of synergy • Overview about cooperation in CEBE • Formal results (PhD defences, patents, publications, projects, external cooperation)

5. How CEBE Was Born National program (EU Structural Funds): „Development of Centres of Excellence in Research“ Period: 2008-2015 Number of candidates – 24 Each consortium consisted of research groups who had a target financed project (financed from Ministry of Education) 7 + 5 centres (in 2011) were selected CEBE is one of the 12 Centres

6. Estonian 12 Excellence Centres 2008 Tartu • Genomics • Chemical Biology • Bio-diversity Research • Translational Medicine • Theory of Culture Tallinn • Computer Science • CEBE 2011 Tartu • Mesosystems • Dark Matter in Particle Physics and Cosmology • Environmental Adaptation • High-Technology Materials for Sustainable Development Tallinn • Nonlinear Studies

7. Mission of CEBE Mission: Improvement of the quality of life through research and technological innovation • Electronics and signal processing Thomas Johan Seebeck Dept. of Electronics, TUT • System design, test, and diagnostics Dept. of Computer Engineering, TUT • Engineering in biology and medicine Technomedicum, TUT Application directions: • Mission-critical and dependable embedded systems • Advancing medical-, food- and biotechnology • Methods, algorithms & tools in signal processing, signal interpretation, design of embedded systems, test and verification

8. Structure of CEBE CEBE Steering Committee TM Tallinn University of Technology ARCHIMEDES TJS DE IAB DCE CEBE Cooperation Projects

9. People and Budget Number of part-time researchers: 45 (22 full positions with average salary of 1400 Eur per month) Number of doctorands: 64 Budget (thousands euros per year):

10. CEBE Competences Impedance spectroscopy Cardiac monitors, stimulators Interpretation of Biosignals Signal processing algorithms Semiconductor technology Optical analysis for dialysis Quality of blood vessels Design of Embedded Systems Investigation of brain signals (EEG) Verification, test anddiagnostics in electronics

11. Health Risk Prevention by Technology Health diagnosis tool Sensors, equipments Risk factors Doctors Risks Biosignals Healthcare plan

12. Generic Distributed ES Architectures Ambient Assisting Technologies Internet Gateway eHealth Middleware Local Data Concentrator

13. Slogan of CEBE - Health2 Nested Health2 Management Concept Biomedical engineering Medical knowledge Engineering knowledge Medical equipments, ICT Design, Development Repair Test, Verification Diagnosis DOCTOR PATIENT System Health Patient’s Health

14. CEBE Research Towards Health2 System design Signal processing algorithms Research in biomedical engineering Applications Bioimpedance spectrography & tomography Medical equipment Design of dedicated processors Pacemakers Design for low power, speed, cost, reliability Brain research, EEG spectral analysis Bioimpedance analysers Mobile EEG analyser Optical dialysis monitoring Design for dependability Equipments for optical signal measurement Optical pulse wave measurement in arteries Verification, design error automated diagnosis and repair Automated testing and fault diagnosis Information for doctors

15. Looking for Synergy > Internal Projects P1 P2 P5 P4 P6 P3 P7 P8 Platform for Embedded System Design

16. Cooperation Synergy Computer Engineering Electronics External impact: Applications Internal impact: Improved Research Excellence EXPECTATIONs: (Two goals of CEBE) Research excellence Applications Technomedicum

17. Cooperation Projects • P1. Application Specific Processors for Signal Processing in Biomedicine (E/CE – M.Min) Results: Methods of signal generation and processing forbroad-band impedance spectroscopy withimplementations in medicine and engineering New specific signal processor architectures (P.Ellervee) Products: Pacemakers (Cooperation with St.Jude Medical, USA) Impedance-spectroscopy measurement equipment QUADRA (Cooperation with Enterprise Estonia, start-up company Prototuba OÜ) Inventor prof. Mart Min was nominated among 3 selected candidates for the European Inventor Award 2011

18. Cooperation Projects • P2. Verification, debug, DFT of Systems (CE: D/V – R.Ubar/J.Raik) Results: Methods for verification and automated debug of systems (J.Raik, M.Jenihhin) Prototype: Fast fault simulator (speed-up 5-10 times, compared to commercial analogs) (S.Devadze) Newtestability marker, easily to be calculated from the circuit structure Characterizes the circuit complexity

19. Cooperation Projects • P2. Verification, debug, DFT (CE: D/V – R.Ubar/J.Raik) Result: New family of benchmark circuits ordered by the complexity (by the values of the testability marker) Cost of processing (time) Test generation Fault simulation Test length Complexity Sharing of resources  Increase of complexity

20. Cooperation Projects • P2. Verification, debug, DFT (CE: D/V – R.Ubar/J.Raik) Result: Novel at-speed on-line functional test method for signal processors (by using inherent specific signals instead of LFSRs or ATPG tests) (M.Gorev) Fault coverage LFSR Chirp Sine Sawtooth Signal processor Test length

21. HLDD Verification and Design Repair Implementation Specification • P2. Verification, debug, DFT of systems Each graph is represented by unique polynomials as a canonical model of the system Implementation Specification Decision Diagrams Bug Novelty: A new possibility for formal verification of digital systems,design error detection and automated repair

22. Managing the Complexity with HLDDs High-Level Decision Diagrams Program data flow D E Behavior of A State space C A=FA1 (...) B B=FB1 (...) C=FC1 (...) A=FA2 (B,C,...) Novelty: Instead of reasoning the design as a whole, it will be partitioned into the behavioral sub-models of functional variables (HLDDs) A=FAn (D,E,...)

23. Cooperation Projects • P3. Total Peripheral Resistance (E/TM – K.Meigas) Results: Methods for continuous and noninvasive optical monitoring of blood pressure and diagnosis of atherosclerosis Distinguishing high sudden death risk patients in various heart diseases Product: Software for commercial Holter monitor devices By spin-off company Tensiotrace OÜ, Estonia Clinical experiments in the hospital PERH, Estonia

24. Cooperation Projects • P4. Evaluation of mental disorders using EEG analyser (CE/TM – M.Jenihhin/H.Hinrikus) Results: EEG spectral asymmetry index was invented (SASI algorithm), which allowed to develop a new method for determining depressive disorders by measuring EEG signals of the brain (H.Hinrikus) Prototype: Portable EEG analyzer for detecting mental disorders (M.Jenihhin) Clinical experiments are going on

25. Cooperation Projects • P5. Reliable and disturbance free monitoring of dialysis (CE/TM – I.Fridolin) Results: Methods for multicomponent monitoring of uremic toxins in biofluids during dialysis Product: Medical equipment for dialysis dose monitoring Diasens By Enterprise Estonia, AS Ldiamon

26. Cooperation Projects • P6. Testing of electronic systems (E/CE – A.Jutman) • Results: Methods and a system forautomated test program synthesis for electronic boards • Methods and high-performance embedded instrumentation in electronic boards • Products: • Microprocessor models for testing • Embedded instrumentation IPs for testing of PCBs and IC chips (Göpel Electronics GmbH, Germany) • BERT (Bit-Error-Rate) Test Equipment (CERN, Switzerland) By spin-off Testonica Lab, Estonia

27. Cooperation Projects • P7. Semiconductor Technology (T.Rang) • Results: Two new approaches have been developed to increase the yield in manufacturing of high speed GaAs power diodes • Cooperation partners: • Ioffe Physical-Technical Inst. of Russian Acad. of Sciences, • Power Electronics Dept. (TUT) Products: High speed power GaAs structures using the LPE technology By By Clifton Ltd, Estonia

28. Cooperation Projects • P7. Semiconductor Technology (T.Rang, R.Ubar) Goals: Defect-oriented Testing with advanced fault models Multiple fault Resistive bridge fault 0 1 0 1 Defect SAF X-fault Byzantine fault Bridges Stuck-opens Multiple faulty signal Conditional fault Pattern fault Constrained SAF Single faulty signal

29. Algorithms, solutions Architectures, components Signal source, sensors Design space exploration Dependable ES Design Platform Novel methods in design for dependability: Platformbased design environment for dependable embedded systems • Faultsimulation • Automated synthesisand analysis of test programs • Systemverification and design error diagnosis • Automated designerror repair • Dependability of NoC-based System-on-Chips Prototype

30. D&T Environment for Research Possibility for wide range of experimental scenarios

31. CEBE International Cooperation • Europrojects during 2011-2015 • FP7: - SAFEMETAL (2010 - 2012) • FP7: -CREDES(2010 - 2012) • FP7: Diagnosis, Error Modelling and Correction for Reliable Systems Design - DIAMOND (2011 - 2013) • FP7: - Innovative, Highly Efficient Road Surface Measurement and Control System - HERMES (2012 - 2014) • FP7: BASTION(2014 - 2016) – (CEBE + Testonica Lab) • Organized international conferences • Baltic Electronic Conferences (2008, 2010, 2012) • Nordic Test Forum (2011) • IEEE Norchip Conference (2012), IEEE DDECS Workshop (2012) • BELAS – European – LatinAmerican Workshop (2013) • HiPEAC Computing Systems Week (2013)

32. Cooperation Partners of CEBE • The partners of CEBE in Estonian industry • ELIKO, Artec Group, Smartimplant, Cybernetica AS, National Semiconductor Eesti, Clifton AS, JR Medical, Elcoteq, AS LDI, LDIAMON AS, Emros OÜ, Tensiotrace OÜ, Girf OÜ, AB Medical Teeninduse OÜ, a.o. • 2 clinics , 4 Estonian hospitals • International cooperation • IBM, Ericsson, St. Jude Medical, Boston Scientific, National Semiconductor,Analog Devices, TDI Inc, Göpel Electronic, STMicroelectronics, AerieLogic, TransEda, a.o.

33. Concluding Statistics • Some numbers about CEBE (last 4/5 years): • 13 international projects (5 FP7), 25+ national grants • 25 PhD thesis defended • 452 publications (170 journal and 273 conf. papers) • Cooperation with 10 industrial partners from Estonia and more than 30 institutions from 15 countries • 15 patents and 11 patent applications • Spin-off companies: 4 (Testonica Lab, Tensiotrace OÜ, Optofluid Technologies OÜ, Prototuba OÜ) • Products: 9 • International evalvation of CEBE (End of 2011) Grade: 5 - Excellent (Application was 4,5) Thank you!