1. HER2 METASTATIC BREAST CANCER & ITS NEW TREATMENT HER2-positive metastatic breast cancer is a subtype of breast cancer where the cancer cells overexpress the HER2 protein, leading to more aggressive cancer growth and increased risk of metastasis. There are several treatments available for HER2-positive metastatic breast cancer, including chemotherapy, targeted therapy, hormone therapy, and immunotherapy. One new treatment option is Tucatinib (Tukysa), which was approved by the US FDA in 2020. Tucatinib is a small molecule tyrosine kinase inhibitor that targets HER2, and it has shown promising results in clinical trials. In a phase 3 trial, the addition of tucatinib to standard treatment (trastuzumab and capecitabine) resulted in a significant improvement in progression-free survival and overall survival compared to standard treatment alone. Other newer treatments that have been approved for HER2-positive metastatic breast cancer include trastuzumab deruxtecan (Enhertu), a HER2-targeted antibody-drug conjugate, and fam- trastuzumab deruxtecan-nxki (Zynlonta), another antibody-drug conjugate. Both drugs have shown promising results in clinical trials and have been approved for patients who have received at least two prior anti-HER2 treatments. It's important to note that the best treatment for HER2-positive metastatic breast cancer will depend on the individual patient's medical history, tumor characteristics, and other factors. Patients should discuss all treatment options with their healthcare providers to make an informed decision about their care.

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