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Viability and Caspase Activity in Cancer Cells Treated with Inhibitors and TNF-α

This study investigates the impact of various compounds (SW.43, SW.IV-52s, SW.III-123) on the viability of cancer cell lines SKOV-3, CaOV-3, and BG-1 after 48 hours of treatment. The analysis includes cell viability percentages and caspase-3 activity in response to TNF-α antibody administration. The results demonstrate varying sensitivities among the cell lines depending on the concentration of the compounds used and the effects of TNF-α on caspase activation, highlighting potential pathways for therapeutic intervention in cancer treatment.

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Viability and Caspase Activity in Cancer Cells Treated with Inhibitors and TNF-α

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  1. Figure 1 A SKOV-3, 48h Viable cells (%) SW 43 SW 43 SW 43 ○ ● ■ □ ○ ● ■ □ ○ ● ■ □ SW IV-52s SW IV-52s SW IV-52s SW III-123 SW III-123 SW III-123 SW 43 + SW IV-52s SW 43 + SW IV-52s SW 43 + SW IV-52s Concentration (µM) B CaOV-3, 48h Viable cells (%) Concentration (µM) C BG-1, 48h Viable cells (%) Concentration (µM)

  2. Figure 2 5 min SW III-123 (M) 0 1 3 10 Phospho NF-B p65 NF-B p65 Actin

  3. Figure 3 CaOV-3 cells A - TNF Ab Caspase 3 activity (fold) + TNF Ab SW IV-52s SW 43 SW III-123 B SW 43 Viable cells (%) SW 43 + TNF Ab SW 43 (µM) C Viable cells (%) SW IV-52s SW IV-52s + TNF Ab SW IV-52s (µM) D Viable cells (%) SW III-123 SW III-123 + TNF Ab SW III-123 (µM)

  4. Figure 4 BG-1 cells A B Viable cells (%) SW 43 SW 43 + TNF Ab Caspase 3 activity (fold) - TNF Ab + TNF Ab SW 43 (µM) C SW IV-52s SW 43 SW III-123 Viable cells (%) SW IV-52s SW IV-52s + TNF Ab SW IV-52s (µM) D Viable cells (%) SW III-123 SW III-123 + TNF Ab SW III-123 (µM)

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