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The Role of Cytokines and Growth Factors in Angiogenesis Regulation

This study explores the intricate roles of various cytokines and growth factors such as IL-18, IFN-g, IL-2, VEGF, FGF, and TNF-a in the regulation of angiogenesis. It examines the impact of these molecules on macrophage migration, T-cell activation, and overall immune response. Understanding the interplay between angiogenic and angiostatic factors, including MIF and ICAMs, could provide insights into therapeutic strategies for inflammatory and proliferative diseases. The findings highlight potential targets for drug development in the management of diseases characterized by abnormal angiogenesis.

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The Role of Cytokines and Growth Factors in Angiogenesis Regulation

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  1. MIF

  2. MIF MMP IL-18 IFN-g IL-2 Angiogenesis VEGF, FGF, HGF IL-8, angipoietin-1 Stromal cell derived GF TNF, TGF (indirect) Angiostatic IL-12,IFN-a b g, PF4 Adhesion molecules ICAM-1,2 VAM-1 *b-integrin LAF-3 *P-selectin BMP MIF MIF Anti-glucocorticoid effects IL-1 & TNF-a TNF-a IL-1 IL-6 IL-7 IL-8 IL18 MIF angiopoietin-1 SDGF, FGF IgG IL-1 TNF-a GM-CSF IL-6 MIF IL-12 IL-18 IFN-g IL-2 IL-4 IL-6 IL-5 IL-17 MIF B Macrophage migration inhibitory factor MIF MIF effector T-cells MIF T T1,2 K Tc NK-IFN-g

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