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The relationship between risk factors and histology in lung cancer

The relationship between risk factors and histology in lung cancer. The map of lung cancer in Turkey. Turkish Thoracic Society Lung and Pleural Malignancies Study Group. 9 provinces, 25 cent e r s , 105 investigators. Method.

jeremy-benjamin
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The relationship between risk factors and histology in lung cancer

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  1. The relationship between risk factors and histology in lung cancer The map of lung cancer in Turkey Turkish Thoracic Society Lung and Pleural Malignancies Study Group

  2. 9 provinces, 25 centers, 105 investigators

  3. Method • Analysis of data of “The project of the map of lung cancer in Turkey” • The aim of the study was to investigate the relationship between risk factors and histology in lung cancer • The project of the map of lung cancer in Turkey • The patient diagnosed as primary lung cancer between 01.01.2005 and 31.12.2005 • 9 provinces, 25 centers, 105 investigators • The provinces of incidence: İzmir, Bursa, Trabzon, Erzurum, Sivas, Diyarbakır, Antalya • Ankara, İstanbul

  4. Age-standardised incidence rates Total: M: 41.7 F: 4.8 n/100.000 Trabzon M: 48.9 F: 4.1 Bursa M: 35.5 F: 3.5 Erzurum M: 36.5 F: 5.2 Sivas M: 38.7 F: 6.6 İzmir M: 57.3 F: 6.2 Diyarbakır M: 13.7 F: 2.1 Antalya M: 25.8 F: 3.4

  5. Histological types NSCLC 5259 71.9%

  6. Risk factors

  7. Age-specific incidence rate n/100.000 Male

  8. Age-specific incidence rate n/100.000 Female

  9. Sex & Age • Total 7303 cases • Sex Male: 90.5% Female: 9.5% • Age • All group: Mean: 60.7 + 10.7 (21 -105) • Male • Mean: 60.7 + 10.5 • Peak value of incidence: 70-74300/100.000 • Kadın • Mean : 60.9 + 12.5 • Peak value of incidence: 80-8445/100.000

  10. Age groups & Histological types Large Small Squamous Adeno Total Total P<0.01

  11. Age groups & Histological types 45 age ↓ 45 age ↑ Total P<0.01

  12. Sex & Histological types

  13. Provinces & Histological types Total

  14. Smoking & Histological types

  15. Smoking & Histological types Comparison according to packet year

  16. Passive smoking & Histological types

  17. Smoking & Histological typesfilter & no filter P=0.00

  18. Smoking & Histological typesRoller tobacco No Yes Total P=0.00

  19. Environmental asbestos exposure

  20. Environmental asbestos exposure& Histological types

  21. COPD & Histological types

  22. Fibrotic scar due to TB & Histological types

  23. Heating systems & Histological types

  24. Previous cancer & Histological types Previous cancer No Yes Total P=0.113

  25. Lung cancer in family & Histological types P=0.018

  26. RESULTS-1 • Squamous cell is the most frequent type • Adenocancer is the most frequent type below • Younger patients • Females • Non.smokers • Passive smokers • Adenocancer • 80% of them are smokers; there is a relationship with smoking • By changing smoking style, adenocancer increasing • More developed cities and young people • Adenocancer may be first type in next 20 years in Turkey

  27. RESULTS-2 • There is no influence asbestos exposure on histological type • Adenocancer is not the most common type among patients with fibrotic scar due to TB • Indoor smoke increases risk of squamous type; while decreasing indoor smoke risk, adenocancer increasing • Cancer history increases risk of adenocancer • Genetic susceptibility & adenocancer?

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