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P eople in Indonesia who suffers OSTEOPOROSIS increases a bout 41,4% in each year.

14 million of post-menopausal women all over the world had lower bone density. (Ana et.al., 2005). 53,6% of above 70-years-old women in Indonesia suffers OSTEOPOROSIS . P eople in Indonesia who suffers OSTEOPOROSIS increases a bout 41,4% in each year. (Suherman & Tobing, 2006).

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P eople in Indonesia who suffers OSTEOPOROSIS increases a bout 41,4% in each year.

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  1. 14 million of post-menopausal women all over the world had lower bone density. (Ana et.al., 2005) 53,6%of above 70-years-old women in Indonesia suffers OSTEOPOROSIS. People in Indonesia who suffers OSTEOPOROSIS increases about 41,4%in each year. (Suherman & Tobing, 2006) (Rachman & Setiyohadi, 2007)

  2. (Manolagas, 2010)

  3. Ellagic acid • Punicalagin • Anthocyanin • Vitamin C (12%) • Vitamin E (4%) • Vitamin B1, B2, B3, • B5, B6, B9 • Vitamin K (16%)

  4. To assess the antioxidant effect of pomegranate juice on mandibular bone remodeling in post-menopausal osteoporosis. Bone Collagen Type I

  5. Sensitive and specific biomarker for measuring osteoclast activity (Chubb, 2012)

  6. Osteoblast

  7. Osteoclast

  8. Ovariectomized Rats without Pomegranate

  9. C-Telopeptide

  10. Daily consumption of pomegranate juice as antioxidant have a contribution in preventing the fragility of mandibular bone that occurs in post-menopausal osteoporosis.

  11. Further development of the research to post-menopausal women as its sample. • Daily consumption of pomegranate juice may be a simple therapy for post-menopausal osteoporosis.

  12. Ana et. al., 2005. Periodontitits and Osteoporosis. Medicine and Biology 12 (2): 100-3. Rachman & Setiyohadi, 2007. Penyakit Osteoporosis. http://www.medicastore.com/osteoporosis/index.html. Accessed on 12 Desember 2012. Suherman & Tobing, 2006. Osteoporosis, Perhimpunan Osteoporosis Indonesia (PEROSI) 1: 1-28. Manolagas SC. From Estrogen-Centric to Aging and OxidativeStress: A Revised Perspective of the Pathogenesis of Osteoporosis, Endocrine Reviews, June 2010, 31(3):266–300 Kang NN, 2012. Oxidative Stress and the Risk of Osteoporosis: The Role of Dietary Polyphenols and Nutritional Supplements in Postmenopausal Women. Thesis Department of Nutritional Sciences University of Toronto.

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