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A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton

A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, OX11 0QX, UK. To see small things – you need a big thing …. What can neutrons and muons do?. ’Neutrons (and muons) tell you where atoms are and what atoms do’.

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A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton

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  1. A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, OX11 0QX, UK.

  2. To see small things – you need a big thing …

  3. What can neutrons and muons do? ’Neutrons (and muons) tell you where atoms are and what atoms do’

  4. Diamond Graphite Fullerene

  5. NeutronDiffraction

  6. InelasticNeutronScattering

  7. Time of flight method Momentum – k (velocity) Energy - E Particle Wave Wavelength – λ (length scale) 20 m 1000 m/s 20 ms μs 10-10 m

  8. From hydrogen … … to hydrogenase Neutrons see the world in a unique way Length and time scales 10-11 – 10-6 m 10-14 – 10-6 s

  9. … to hydrogenase Neutrons see the world in a unique way From hydrogen … Length and time scales 10-11 – 10-6 m 10-14 – 10-6 s

  10. Neutrons see the world in a unique way

  11. Neutrons see the world in a unique way Penetration Large samples, buried interfaces, non-destructive

  12. Neutrons see the world in a unique way Magnetism The neutron has a magnetic moment but no charge

  13. + + = Neutrons see the world in a unique way Sensistivity and selectivity Isotopic substitution/contrast variation

  14. a(4K) = 14.04212(2) Å 18th order spherical harmonic c18,1 = -0.020; c18,2 = 0.077 Neutrons see the world in a unique way Precision Weak interaction, simple interaction

  15. Crystallography Powder diffraction HRPD POLARIS GEM HiPr (ROTAX) WISH (TS2) Single crystal diffraction SXD Engineering diffraction ENGIN-X

  16. Single crystal diffraction - SXD

  17. Anticancer drug studied on SXD in 2005 C. K. Broder et al.

  18. Anticancer drug studied on SXD in 2005 C. K. Broder et al.

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