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Academic Careers in Lung Stem Cells/Cell Therapies/Bioengineering.

Academic Careers in Lung Stem Cells/Cell Therapies/Bioengineering. Sara Lin, Ph.D. Program Director Developmental Biology and Pediatrics Division of Lung Diseases NHLBI September 9, 2013. NIH Mission. Acquire new knowledge leading to better health Support research

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Academic Careers in Lung Stem Cells/Cell Therapies/Bioengineering.

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  1. Academic Careers in Lung Stem Cells/Cell Therapies/Bioengineering. Sara Lin, Ph.D. Program Director Developmental Biology and Pediatrics Division of Lung Diseases NHLBI September 9, 2013

  2. NIH Mission • Acquire new knowledge leading to better health • Support research • Train early career investigators • Communicate research results to the medical community and the public

  3. NHLBI Competing Research Project Grant Applications FY 2002 to 2012 Source NHLBI Fact Book FY2012

  4. Overview • Plan: Find Your Path • Focus: Scientific Area and Questions • Act: Submit Your Best Application • Resources

  5. Plan: Find Your Path TRAINING Pre-BAC Institutional Training Grant (T34) Institutional Training Grant (T32) GRAD/MED STUDENT Individual NRSA Fellowship (F30/31) Institutional Training Grant (T32) POST-DOCTORAL Individual NRSA Fellowship (F32) CAREER Pathway to Independence Award (K99/R00) Mentored Res. Sci. Dev. Award (K01) Mentored Clin. Sci. Dev. Award (K08) Mentored Patient-Oriented RCDA (K23) Early Development Ind. Researcher Res Grants: R01/ESI

  6. http://grants.nih.gov/training/careerdevelopmentawards.htm

  7. Pathways to Independence Award (K99/R00) • Five years of support in two phases: • 1-2 years of mentored postdoctoral research • 3 years of independent support (R00) contingent on securing an independent research position • 4 years limit (starting Feb. 12, 2014 ) • Open to MDs or PhDs in postdoctoral status • US citizenship is NOT required

  8. Transitioning from a K99 to R00 Award and Beyond – NIH Data 190 K99 grants were awarded by NIH in FY2007 NHLBI funded 39 K99 awards in FY 12 (30% success rate) 167 PhDs; 12 MD/PhDs; 10 MDs; 1 other 94.2% of K99 awardees transitioned to R00 78.9% applied for R01s, with 33.7% receiving R01 Median age at time of R01 award – 37 yrs of age

  9. Early Stage Investigator (ESI) http://grants.nih.gov/grants/new_investigators/index.htm#policies PI who first qualifies as a new investigator AND is within 10 years of completing the terminal research degree or is within 10 years of completing medical residency (or equivalent) For multiple PIs, all must meet requirements for ESI status As a subset of new investigators, ESIs are also eligible for the shortened review cycle option

  10. NHLBI-Early Stage Investigators FY2013 • Type 1 R01 applications (New) • Band I: 5% above Payline • Band II: 6% -10% above Payline (expedited rev) • # of years approved by IRG will not be reduced • Type 2 R01 applications (First renewal) • 5% above Payline

  11. Focus: Scientific Area and Questions Grant Awards in Lung Repair Regeneration New Continued Overall NHLBI Funding

  12. Scientific Programs Supported by NHLBI • Lung Repair and Regeneration Consortium (LRRC) • https://www.lungrepair.org/ • Progenitor Cell Biology Consortium (PCBC) • http://www.progenitorcells.org/ • Cardiovascular Cell Therapy Research Network (CCTRN) • https://ccct.sph.uth.tmc.edu/cctrn/

  13. Lung Repair and Regeneration Consortium • https://www.lungrepair.org/

  14. Progenitor Cell Biology Consortium • http://www.progenitorcells.org/

  15. Cardiovascular Cell Therapy Research Network • https://ccct.sph.uth.tmc.edu/cctrn/

  16. Recent RFAs Supported by NHLBI • RFA-HL-11-025 New Strategies for Growing 3D Tissues (R01) • RFA-HL-11-006 Next Generation Genetic Association Studies (U01) • RFA-HL-14-007, -008, -009 Molecular Atlas of Lung Development (U01)

  17. Develop a Compelling Scientific Question • Why is your research IMPORTANT and TIMELY, and what is it going to ACCOMPLISH? • How will your research impact health, and make a real difference? • Does your research fill a gap? Is it innovative? • Clearly define your scientific objective and the fundamental advance your research will make • Focus • Be productive (publish!)

  18. Get your Application Funded • Be explicit in your application: don’t make assumptions about the peer review(ers). State feasibility. • Identify the Institute(s) best aligned with your scientific goals, and talk with a program officer before submitting an application. • Peer-review determines the merit of applications, not an Institute or program officer. • Get it right the first time: don’t rely on a revision • Be persistent

  19. Mentor/Mentoring • Science & Career Development • Track Record • Availability • Style and Philosophy • Not just ONE individual • Your mentor should read your proposal • You should give your mentor sufficient time to read your proposal (weeks, not days)

  20. Available Resources

  21. NHLBI Homepage

  22. Workshops Supported by NHLBI • Meeting Summaries and Scientific Reports • http://www.nhlbi.nih.gov/resources/docs/index.htm

  23. Workshops Supported by NHLBI • Cell Therapy for Pediatric Diseases: A Growing Frontier Production Assistance for Cellular Therapies (PACT) Workshop 2011 • http://www.nhlbi.nih.gov/meetings/workshops/pact.htm • Cell Therapy for Lung Diseases 2012 • http://www.nhlbi.nih.gov/meetings/workshops/cell-therapy.htm • Molecular Determinants of Lung Development 2011 • http://www.nhlbi.nih.gov/meetings/workshops/molecular.htm • Cellular Plasticity in Lung Injury and Repair 2010 • http://www.nhlbi.nih.gov/meetings/workshops/cellular-plasticity.htm

  24. 2013 Funding Opportunity Announcements

  25. Resources Available from NHLBI • Lung Tissue Research Consortium (LTRC) • Microarray Resources • Production of Assistance for Cellular Therapies (PACT) • Resequencing and Genotyping Service (RS&G) • Trans-NIH Mouse Initiatives • Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases • Gene Therapy Resource Program (GTRP) • SMARTT • See http://www.nhlbi.nih.gov/resources/resources.htm

  26. NIH-Research Portfolio Online Reporting Tools http://report.nih.gov/

  27. NIH Common Fund

  28. Trans-Agency Collaborative Activities • Multi-Agency Tissue Engineering Science • http://tissueengineering.gov/agencies.htm

  29. Contact NIH Staff for Questions • NIH training • http://grants1.nih.gov/training • NIH Center for Scientific Review • http://public.csr.nih.gov/Pages/default.aspx • Office of Laboratory Animal Welfare (OLAW) • http://olaw/grants/olaw/olaw.htm • NIH Project Reporter • http://projectreporter.nih.gov/reporter.cfm

  30. Grant-Writing Advice and Resources • NIH Center for Scientific Review: http://public.csr.nih.gov • NIH Office Extramural Research: http://grants.nih.gov • http://sciencecareers.sciencemag.org// • NIH Director’s Early Independence Award (DP5) http://commonfund.nih.gov/earlyindependence/ • NIH’s Early Stage Investigator Policies: http://grants.nih.gov/grants/new_investigators/index.htm#policies • Scott JD and Carlson DE. K08 and K99 Cardiovascular Training: Comparisons and Trends Among Current Awardees.Circ Res 2012; 110:910-914 • Accompanying Editorial: Houser SR. How to Obtain an NHLBI-Sponsored K08 and K99/R00 Grant in the Current Funding Climate. Circ Res 2012:110-907-909

  31. DLD Staff Directory • Cystic Fibrosis • Susan Banks-Schlegel, Ph.D • Chronic Obstructive Pulmonary Disease/Environment • Antonello Punturieri, M.D., Ph.D. • Lisa Postow, Ph.D. • Asthma • Patricia Noel, Ph.D. • Susan Banks-Schlegel, Ph.D. • Virginia Taggart, M.P.H. • Michelle Freemer, M.D. • AIRWAY BIOLOGY AND DISEASE BRANCH • Phone: 301-435-0202Fax: 301-480-5577 • Thomas Croxton, Ph.D., M.D. (Chief) • Genetics, Genomics, and Advanced Technologies • Weiniu Gan, Ph.D. • Training and Special Programs • Xenia Tigno, Ph.D. • AIDS/Tuberculosis • Hannah Peavy, M.D. • Sandra Colombini Hatch, M.D • Elisabet Caler, Ph.D. • LUNG BIOLOGY AND DISEASE BRANCH • Phone: 301-435-0222Fax: 301-480-3557 • Timothy Moore, M.D., Ph.D. (Chief) • Developmental Biology • Pediatrics • Carol Blaisdell, M.D. • Sara Lin, Ph.D. • Critical Care/Acute Lung Injury • Andrea Harabin, Ph.D. • Lung Cell/Vascular Biology • Timothy Moore, M.D., Ph.D. • (Acting) • Training and Special Programs • Sandra Colombini Hatch, M.D. • OFFICE OF THE DIRECTOR • Phone: 301-435-0233 • Fax: 301-480-3547 • James Kiley, Ph.D. (Director)Gail Weinmann, M.D. (Deputy Director) • Immunology/Fibrosis • Jerry Eu, M.D. • NATIONAL CENTER ON SLEEP DISORDERS RESEARCH • Phone: 301-435-0199Fax: 301-480-3451 • Michael Twery, Ph.D. (Director) • Sleep Disorders Medicine • Michael Twery, Ph.D. • (Acting) • Neurobiology/Sleep • Aaron D. Laposky, Ph.D.

  32. NIH Home Page - www.nih.gov • Additional Program Information • Staff Contacts • NIH Guide • Grant Policy • Applications

  33. http://grants.nih.gov/grants/about_grants.htm

  34. http://public.csr.nih.gov/Pages/default.aspx

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