1 / 7

Zika Virus in Pregnancy

Zika Virus in Pregnancy. Max Brinsmead MB BS PhD October 2018. Zika Virus. Caused by a Favivirus related to yellow fever, dengue, West Nile and Japanese encephalitis

jrachael
Télécharger la présentation

Zika Virus in Pregnancy

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Zika Virus in Pregnancy Max Brinsmead MB BS PhD October 2018

  2. Zika Virus • Caused by a Favivirus related to yellow fever, dengue, West Nile and Japanese encephalitis • First noted in central Africa in monkeys in 1947, but appeared in Pacific Islands in 2007, then noted to be spreading as a pandemic from South towards North America in 2014 • Transmitted by mosquitoes mostly Ae. aegypti • This mosquito found only in far N Queensland

  3. Zika Virus Infection • Causes a mild febrile illness in adults • Begins with headache • Maculopapular rash (variable) • Myalgia and Arthralgia • Conjunctivitis • Diagnosis • ELISA for IgM and IgG • Some cross reactivity with dengue • PCR for acute phase viral RNA • Zika virus particles and RNA • Found in fetal brain in mid trimester • With progressive microcephaly seen after maternal infection

  4. Zika Virus in Pregnancy • Apparent transplacentalwith progressive fetalmicrocepahy and brain calcifications • Transmission Risk – Emerging data • Best data from a prospective study in French American territories • Overall 13% 1st trimester and 5.5% 3rd trimester • Microcephaly rate 5.8% of which 1.6% severe • American CDC recommends that any woman who has travelled to a known endemic area and who has two or more symptoms should be tested for ZV IgG • Monitor fetus with ultrasound and • Refer to a Perinatal Specialist Unit for management • No treatment available

  5. Prevention • Pregnant women should avoid travel to areas known to harbourZika Virus • Check current maps and guidelines • Avoid mosquito bites • Very low risk of transmission in Australia as most areas do not have the appropriate species of mosquito that would act as a vector

  6. Sexual Transmission of Zika Virus • Zika Virus can be transmitted sexually • The transmission risk is LOW • But it can be transmitted before a person becomes symptomatic • And possibly by asymptomatic persons • It has been detected in semen for quite long periods • Up to 6 months after infection • Mean clearance from serum was 84 days • 95% cleared in 4 months • Women whose partner has or may have Zika are advised to avoid pregnancy • Check how long with current guidelines • Women in Zika areas are advised to use condoms or avoid sex during pregnancy

  7. Any Questions? Please post a Note on the Welcome Page to this website

More Related