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GI Pathology II, Case 5

GI Pathology II, Case 5. 50-year-old man has sigmoidoscopy to evaluate for GI pathology. A Villous Adenoma B Tubular Adenoma. Describe the histologic findings. Diagnosis?. Villous adenoma. Normal colonic mucosa. Villous Adenoma

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GI Pathology II, Case 5

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  1. GI Pathology II, Case 5 • 50-year-old man has sigmoidoscopy to evaluate for GI pathology

  2. A Villous Adenoma B Tubular Adenoma

  3. Describe the histologic findings. Diagnosis?

  4. Villous adenoma Normal colonic mucosa Villous Adenoma A low power view of the colonic mucosa revelas a benign neoplasm composed of villi or "finger-like" mucosal projections (*). The adjacent mucosa contains normal glands.

  5. Describe the histologic changes on this lower power image

  6. A section of the colon reveals a broad based polyp which for the most part forms villi (>50%)

  7. Describe the histologic changes

  8. Villi are lined by an epithelium which is dysplastic, with cells containing enlarged, hyperchromatic and pseudostratified epithelium

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