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Histopathological Analysis of Tubular Adenoma in a 60-Year-Old Woman with Anemia

This case presents a 60-year-old woman exhibiting easy fatigability and a hemoglobin level of 10.2 g/100 ml. Histological examination reveals the identification of structures such as tubular adenomas and normal adjacent colon mucosa. The crowded, disorganized glands of the tubular adenoma are characterized by hyperchromatic nuclei and are lined with goblet cells and atypical epithelium. Importantly, there is no evidence of stalk invasion, confirming the benign nature of the polyps. Key histological findings include goblet cells, hyperchromatic nuclei, and the absence of invasion.

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Histopathological Analysis of Tubular Adenoma in a 60-Year-Old Woman with Anemia

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Presentation Transcript

  1. GI Pathology II, Case 4 • 60-year-old woman with easy fatiguability and hemoglobin of 10.2 g/100ml.

  2. Identify the structures

  3. A Villous Adenoma B Tubular Adenoma

  4. Tubular Adenomas Polyp Stalk Normal adjacent colon mucosa Normal adjacent colon mucosa Even on low power note the crowded, disorganized glands of the tubular adenoma compared to the normal underlying colonic mucosa. The cells lining the glands of the polyp have hyperchromatic nuclei. There is no stalk invasion – the polyps are benign

  5. Describe the histologic findings

  6. Goblet cells Hyperchromatic nuclei The glands of the tubular adenoma are lined by goblet cells and epithelium with elongated cells containing hyperchromatic nuclei that are pseudostratified (atypical or “dysplastic” epithelium) There is no invasion of the lamina propria or submucosa.

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