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Featured Article :

Featured Article :. Glucose-Lowering Effects and Low Risk of Hypoglycemia in Patients With Maturity-Onset Diabetes of the Young When Treated With a GLP-1 Receptor Agonist: ADouble- Blind, Randomized, Crossover Trial. Signe H. Østoft, Jonatan I. Bagger, Torben Hansen, Oluf Pedersen,

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Featured Article :

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  1. Featured Article: Glucose-Lowering Effects and Low Risk of Hypoglycemia in Patients With Maturity-Onset Diabetes of the Young When Treated With a GLP-1 Receptor Agonist: ADouble- Blind, Randomized, Crossover Trial Signe H. Østoft, Jonatan I. Bagger, Torben Hansen, Oluf Pedersen, Jens Faber, Jens J. Holst, Filip K. Knop, and Tina Vilsbøll Diabetes Care Volume 37: 1797-1805 July, 2014

  2. STUDY OBJECTIVE • Hepatocyte nuclear factor 1 (HNF1A diabetes) is often treated with sulfonylureas that confer a high risk of hypoglycemia • We evaluated treatment with GLP-1 receptor agonists (GLP-1RAs) in patients with HNF1A diabetes Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

  3. STUDY DESIGN AND METHODS • 16 patients with HNF1A diabetes received 6 weeks of treatment with a GLP-1RA (liraglutide) and placebo (tablets), as well as a sulfonylurea (glimepiride) and placebo (injections) • Glimepiride was up-titrated once weekly in a treat-to-target manner • Liraglutide was up-titrated once weekly to 1.8 mg once daily • At baseline and at the end of each treatment period, a standardized liquid meal test was performed, including a 30-min light bicycle test Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

  4. Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

  5. RESULTS • Fasting plasma glucose (FPG) decreased during the treatment periods, with no difference between treatments • Postprandial plasma glucose (PG) responses were lower with both glimepiride and liraglutide compared with baseline, with no difference between treatments • 18 episodes of hypoglycemia occurred during glimepiride treatment and one during liraglutide treatment Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

  6. Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

  7. Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

  8. CONCLUSIONS • Six weeks of treatment with glimepiride or liraglutide lowered FPG and postprandial glucose excursions in patients with HNF1A diabetes • Glucose-lowering effect was greater with glimepiride at the expense of a higher risk of exclusively mild hypoglycemia Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

  9. Østoft S. H. et al. Diabetes Care 2014;37:1797-1805

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