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Unleashing Metabolomics: The New Frontier in Disease Detection and Treatment

Metabolomics, a pivotal component of modern biology, is reshaping our understanding of disease mechanisms following the completion of the human genome project. With a focus on the functionalities of sequenced genes, it's revolutionizing disease detection and treatment strategies, particularly in cancer research. Initiatives by NCI emphasize the integration of metabolomics with proteomics and nanotechnology, highlighting the potential of small molecules and metabolites in revealing cellular pathophysiology and developing novel therapeutic targets.

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Unleashing Metabolomics: The New Frontier in Disease Detection and Treatment

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  1. Metabolomics: An Untapped Frontier • Since the completion of the human gene sequence, • the focus has shifted on the function of sequenced • genes and their roles in disease detection and • treatment. • Proteomics along with other ‘omics’ are • revolutionizing our approaches to disease detection. • Cancer detection remains a high priority for NCI and • numerous initiatives on proteomics, nanotechnolgy • have been launched.

  2. Metabolomics Workshop Sudhir Srivastava, Ph.D., MPH Chief, Cancer Biomarkers Research Group Division of Cancer Prevention National Cancer Institute, NIH

  3. This is a Century of Small Molecules Then Now Aptamers DNA Micro RNA RNA Proteomics, Glycomics Metabolomics Protein

  4. The Wonders of Small Molecules • Structurally amenable to targeting by drugs • Likely to shed a lot of information on patho-physiological • state of cells • Likely to be less complex than proteins • Limited in numbers (around 3000 ‘functional’ • metabolites (Beecher)

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