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Alzheimer’s & the possible treatments effects of melatonin and resveratrol

Alzheimer’s & the possible treatments effects of melatonin and resveratrol. Katharine Frost. Need. Figure 1. Segal & Wayne, 2009. Fundamentals. Figure 2. Christensen, 2007. Model Organisms & Types of Alzheimer’s. - Apoe4 gene. Korschun, 2006. Figure 3. Figure 4. Segal & wayne, 2009,.

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Alzheimer’s & the possible treatments effects of melatonin and resveratrol

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  1. Alzheimer’s & the possible treatments effects of melatonin and resveratrol Katharine Frost

  2. Need Figure 1 Segal & Wayne, 2009

  3. Fundamentals Figure 2 Christensen, 2007

  4. Model Organisms & Types of Alzheimer’s - Apoe4 gene Korschun, 2006 Figure 3 Figure 4 Segal & wayne, 2009, PET brain scans reveal plaque and tangle accumulation in patients with the APOE-4 gene, which increases risk of Alzheimer's

  5. Non hereditary Alzheimer’s • Non hereditary Alzheimer’s caused by oxidative stress (Korschun, 2006) • treatments with anti oxidants (Cummings, 2009)

  6. Resveratrol & Melatonin Proteasome function Melatonin levels and age Figure 5 Figure 6 Patton, 2005 Ward, 2009

  7. Literature Review Marambaud Figure 7 mM Marambaud, 2008

  8. Literature Review • Srinivasan (2006) determined that melatonin may also have potential to be a treatment as it increases the survival of neurons under oxidative stress

  9. Purpose and Hypothesis • Purpose: the purpose of this experiment is to find out if resveratrol or melatonin slow down the progression of Alzheimer's disease • Hypothesis: Drosophila treated with resveratrol and drosophila treated with melatonin will show less loss of cognitive ability than flies not treated

  10. Methodology

  11. Budget plan $138.84 total

  12. Do-Ability • do able in the lab because it uses protocols and materials that have all been handled and dealt with before in the lab • Much of the materials needed for caring for the drosophila are already available • Copper mesh, and resveratrol and melatonin would be needed.

  13. Bibliography • Bahr, Marthias; Neuro-protection, Alzheimer's Disease; Neuro-protection; 2004; page 34 • Behkne, John A; Human aging; The biology of aging; published 1978, pages 182- 185 • Conn, Michael; Drosophila models of aging; Handbook of Models for Human Aging; published 2006; pages 253-255 • Christensen, DD; Alzheimer痴 Disease: Progress in the Development of Anti-amyloid Disease-Modifying Therapies; CNS spectrums; Vol 12; 2007; pages 113- 123 • Crowther, Damien; Alzheimer's, Working with Drosophila; www.research-horizons.com; issue 1; October, 2006 • Dead, Ward; Neuroendocrine theory of aging chapter 5; http://www.vrp.com/articles.aspx?ProdID=338; 2009 • Korschun, Holly; Scientists Discover Possible Link Between Oxidative Stress and Non-hereditary Degenerative Disease; http://www.medicalnewstoday.com/articles/42423.php; May 2, 2006 • Marambaud, Philippe; Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-Peptides; The Journal of Biochemistry; Vol 10; November 11, 2005; Pages 316-326 • Patton, Dominique; Resveratrol Tackles Alzheimer's Plaques; http://www.nutraingredients.com/Research/Resveratrol-tackles-Alzheimer-s-plaques-shows-lab-study; November 4, 2005 • Shenk, D; Alzheimers disease; The Columbia Encyclopedia; Vol 6; 2008 • Srinivasan, V; Melatonin in Alzheimer's Disease and other Neurodegenerative Disorders; Behavior Brain Functions; Volume 2; May 4, 2006; 2-15 • Wayne, Melissa and Segal, Jeanne; Alzheimer's Disease Symmptoms and Stages; www.helpguide.org; 2009.

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