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Effects of Cannabanoids on the brain!

Effects of Cannabanoids on the brain!. Delta 9-THC. Psycoactive Cannabinoids. Euphoria Enhancement of sensory perception Tachycardia Antinociception Impairment of memory Difficulties in concentration

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Effects of Cannabanoids on the brain!

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  1. Effects of Cannabanoids on the brain! Delta 9-THC

  2. Psycoactive Cannabinoids • Euphoria • Enhancement of sensory perception • Tachycardia • Antinociception • Impairment of memory • Difficulties in concentration The use of psycoactive cannabinoids increase the activity of Dopamine neurons which are involved in the regulation of motivation and reward. This activation of dopaminergic neurons facilitates the mesolimbic nervous system.

  3. DELTA 9-THC • Induces cell death • Causes shrinkage of Neurons and DNA fragmentation in the hippocampus. THC once in the bloodstream reaches the brain in seconds and then acts on the cannabinoid receptors in the brain activated by the neurotransmitter Anandamide and activates neurons. THC can mimic/block the actions of neurotransmitters and interfere with the normal brain function.

  4. Cannabinoid Receptor sites • There are 3 main • Receptor sites : • Basal Ganglia – • responsible for • unconscious muscle • movements. • Hippocampus – • located in the Temporal Lobe is responsible for short-term • memory. • Cerebellum - responsible for co-ordination.

  5. ‘THE MUNCHIES’ Endocannabinoids bind with receptors in the brain and “activate hunger”. There are 3 neuromodulatory lipids involved in the endocannabinoid system. • Arachidonic Acid • Anandamide • 2-arachidonylglycerol They bind to G protein-coupled receptors (CB1 receptors) in the brain.

  6. G protein-coupled cannabinoid receptors.

  7. Magnetic Resonance Imaging – MRI The real damage caused by the abuse of this class C drug can be seen on an MRI scan. The difference in the amount of brain tissue between the user and the non-user is very evident. The use of cannabinoids affects the limbic system (emotion, reward) and the hippocampus (memory) the greatest.

  8. Cannabinoids and the Brain The effects on the brain of cannabinoids are extreme but there are some known positive effects relating to a few neurological disorders: • Epilepsy • Multiple Sclerosis • Alzheimers Disease • Parkinsons Disease • Schizophrenia

  9. References • cannibus.net • www.nida.nih.gov/infofacts/marijuana.html • Health.howstuffworks.com • www.springer.com • Oxfordjournals.org • www.mindhacks.com • Images.theage.com • Users.lycaeum.org

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