1. Lecture 12LIPID METABOLISMFATTY ACID OXIDATION • September1, 2006 • Lehninger (4th Edition), Chapter 17

2. FATTY ACID DEGRADATION (OXIDATION) LNC Chapter 17

6. LNC 10-1

7. LNC 10-6

8. LNC 10-8

9. LNC 10-15

10. LNC 10-16

11. UPTAKE and DISTRIBUTION in Mammals

12. LNC 17-1

13. ADIPOSE TISSUE LNC 21-40

14. Chylomicron LNC 17-2

15. Structure of an LDL particle LNC 21-39a

16. LNC 21-39b

17. Breakdown/Oxidation of Fatty Acids b-Oxidation

18. Activation LNC 17-5

19. LNC 17-6

20. C14fatty acid 7 acetyl CoA 6 rounds of b oxidation

21. LNC 17-7

22. LNC 19-8

23. How to deal with unsaturated fatty acids: cis D3 - or double bond between b-g LNC 17-9

25. LNC 17-10

26. How to deal with a fatty acid containing an uneven number of carbons C3 C4 LNC 17-11

27. LNC box 17-1

28. LNC box 17-2

31. Degradation of very long chain fatty acids in the peroxisome catalase LNC 17-12

32. succinate Glyoxalate Cycle in Plants LNC 17-13

33. Ketone Bodies

34. Conditions favoring ketone body formation: depletion of OA for gluconeogenesis acetyl-CoA becomes available for ketone body synthesis LNC Fig 17-18

40. Skip the details on the metabolism of ketone bodies

41. Metabolic Biochemistry FATTY ACID SYNTHESIS LNC Chapter 21

42. acetyl-CoA + CO2 ==> malonyl-CoA the enzyme has three functional regions: - biotin carrier protein - biotin carboxylase - transcarboxylase LNC Fig. 21-1

43. LNC Fig. 21-4

44. acyl carrier protein LNC Fig. 21-2

45. LNC Fig. 21-2

46. LNC Fig. 21-2

47. This group is transferred to the other SH group to free the ACP-SH for the next malonyl group LNC Fig. 21-2

48. LNC Fig. 21-3

49. LNC Fig. 21-5

50. LNC Fig. 21-5