1 / 12

Patricia Batista

Patricia Batista. Capsaicin. active component of chili peppers; burning and painful sensations; actives a distinct subpopulation of primary sensory neurons;

kaseem-salas
Télécharger la présentation

Patricia Batista

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Patricia Batista

  2. Capsaicin • active component of chili peppers; • burning and painful sensations; • actives a distinct subpopulation of primary sensory neurons; • TRPV1 also respond to noxious heat (> 43ºC), extracellular protons (pH <6) (Tominaga et al., 1998), and its endogenous ligands as anandamide (Di Marzo et al., 2001), N-arachidonoyl-dopamine (Hwang et al., 2002) and products of lipoxygenases (Hwang et al., 2000).

  3. Steroid Hormones • Effects are mediated by genomic steroid response elements; • Modulate directly excitatory glutamate and GABAA and glycine receptors; • Neurosteroids (DHA and pregnenolone sulfate) inhibit the TRPV1-mediated current in DRG neurons (Chen et al., 2004; Chen and Wu, 2004).

  4. Steroid Hormones

  5. ?????? • There is a sex difference in the capsaicin-induced nocifensive response? • Mechanisms underlying this sex difference?

  6. Sex difference in capsaicin-induced nocifensive response

  7. Estrus cycle difference in capsaicin-induced nocifensive response 6 weeks after OVX Cap ED50 1.5 fold estrus > proestrus Estrus: [E2]plasma Proestrus: [E2]plasma

  8. E2 potentiates the capsaicin-induced nocifensive response in males Bis I -> PKC inhibitor H89 -> PKA inhibitor

  9. L-NAME effect in the cold-induced nocifensive response Cold plate <2ºC

  10. Estrous cycle effect on acetone test in CCI mice 7 days after surgery

  11. Estrous cycle effect on acetone test in CCI mice 14 days after surgery

  12. THANK YOU!!!

More Related