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The Daly Lab

The Daly Lab. Personnel: Postdoctoral: Erich Staudacher Graduate students: Oakland Peters Esther Mwilaria (MS Sp 07) Undergraduate students: Faizan Kalwar Mandy Hatfield Morgan Bridi Tyler Pittman Aarzu Moghal Sawan Phrabhu. Current proposals:

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The Daly Lab

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  1. The Daly Lab • Personnel: • Postdoctoral: • Erich Staudacher • Graduate students: • Oakland Peters • Esther Mwilaria (MS Sp 07) • Undergraduate students: • Faizan Kalwar • Mandy Hatfield • Morgan Bridi • Tyler Pittman • Aarzu Moghal • Sawan Phrabhu • Current proposals: • National Institutes of Health (R01) – NIDCD “The role of periodic input in odor coding” PI: Kevin C. Daly 5 years; (initial score 228; in review). • Human Frontiers in Science. “The virtual 4D antennal lobe: Representation of odor processing in space at spike-time resolution. Score: 30th (in revision for NSF ETA spring 09). • Prior funding: • National Institutes of Health (R03) – NIDCD: “Analysis of combinatorial olfactory coding” Grant number: DC05535; 3 years, $221,000. • McDonnell Foundation collaborative grant: “Hydrodynamic and neural filtering of spatial information in a turbulent odor plume” 3 years $105,000. • National Institutes of Health (R01) – NIDCD “Aminergic modulation underlying olfactory plasticity” PI: Thomas A Christensen 5 years; OSU subcontract: $200,000 Grant number: DC05652. • National Institutes of Health (P20) – NCRR “COBRE in Sensory Neuroscience” PI George Spirou; CoPI: Kevin C. Daly (RR015574-06). 5 year $10,724,104.00: Daly sub award: $1,354,457.00

  2. Wing beating causes oscillating airflow over the antennae Relative amplitude Induced airspeed (m/s) Sane and Jacobson JEB 2006

  3. Oscillating odor stimulus results in oscillating electroantennogram (EAG) up to ~30Hz Power spectral density Integrated power RAW and 5Hz high pass filtered EAG Mean integrated power pulsed odor pulsed blank 3s cont. odor

  4. Oscillating stimulus results in oscillating local field potentials in the antennal lobe up to 72 Hz Mean integrated power pulsed odor pulsed blank 3s cont. odor

  5. A6 A7 A8 A9 A10 K6 K7 K8 K9 K10 B 1.2 0 .2 .4 .6 .8 1 10 10 20 20 30 30 40 40 50 50 50 40 30 20 10 0 .3 10 14 18 20 22 25 30 34 40 .2 .1 0 1 .5 0 -.5 -1 Oscillating stimulus results in oscillating unitary spiking from antennal lobe neurons up to ~40 Hz (extracellular) i ii Odor Mean Power (z-score) Frequency (Hz) Probability stim Peri-stimulusTime (sec) Units Responding (%) Stimulation frequency (Hz)

  6. Oscillating stimulus results in oscillating unitary spiking from antennal lobe neurons up to only ~15 Hz (intracellular) Local interneuron Projection neuron

  7. GABAA disruption results in loss of oscillating responses from antennal lobe LFP and unitary spiking pre bicuculline pre bicuculline Loss of unitary oscillatory responses

  8. Reconstructing whole antennal lobe output responses by serial reconstruction

  9. Virtual population responses from confirmed PN in response to an odor panel

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