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Biochemical Engineering Shigeo Katoh and Fumitake Yoshida Wiley-VCH 2009

Biochemical Engineering. Sub-text. Biochemical Engineering Shigeo Katoh and Fumitake Yoshida Wiley-VCH 2009. Print-outs (Web site). Bioproducts in Japan (2008). Product Amount(billion US$) (%) Ratio of New Biotech(%).

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Biochemical Engineering Shigeo Katoh and Fumitake Yoshida Wiley-VCH 2009

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  1. Biochemical Engineering Sub-text Biochemical Engineering Shigeo Katoh and Fumitake Yoshida Wiley-VCH 2009 Print-outs (Web site)

  2. Bioproducts in Japan (2008) Product Amount(billion US$)(%) Ratio of New Biotech(%) Foods 45 62 0.8 alcoholic beverage 34 seasoning(soy, miso --) 2.6 fermented food 4.6 bread 3.6 Other foods 4.5 6 10 sweetener 1.1 amino acid, peptide, vitamin 1 enzymes 0.5 Medicine 9.3 13 67 antibiotics 0. 7 enzyme, amino acid 1 bio-derived protein 1.2 recombinant medicine 2 antibody 1.3 diagnostic product 1.2 Chemicals 3.6 5 54 cosmetics, detergent --

  3. Scheme of bioprocess

  4. Production of interferon by recombinant E. coli

  5. Microorganisim(Escherichia coli)

  6. Fermentor (Bioreactor)

  7. Downstream Processes

  8. Scheme of bioprocess

  9. Biology Microbiology Biochemistry Genetic Engineering Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography Scheme of bioprocess

  10. Biology Microbiology Biochemistry Genetic Engineering Week 1: Course introduction and Basic concepts (Chaps. 1 & 2) 2: Heat and mass transfer (Chaps. 5 & 6) 3: Fundamental reaction kinetics and enzyme reaction (Chap. 3) 4: Fundamentals of biochemistry and genetic engineering (OHP) 5: Cell kinetics and mode of fermentor operation (Chap. 4 & 12.6) 6: Bioreactors and fermentor design (Chap. 7) 7: Bioreactors and fermentation strategy (Chap. 7 & OHP) 8: Cell separation and other separation methods (Chaps. 8 - 10) 9: Adsorption and chromatography (Chap.11 and OHP) 10: Adsorption and chromatography (Chaps.11, 13 and OHP) EXAM Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography

  11. Biology Microbiology Biochemistry Genetic Engineering Week 1: Course introduction and Basic concepts (Chaps. 1 & 2) 2: Heat and mass transfer (Chaps. 5 & 6) 3: Fundamental reaction kinetics and enzyme reaction (Chap. 3) 4: Fundamentals of biochemistry and genetic engineering (OHP) 5: Cell kinetics and mode of fermentor operation (Chap. 4 & 12.6) 6: Bioreactors and fermentor design (Chap. 7) 7: Bioreactors and fermentation strategy (Chap. 7 & OHP) 8: Cell separation and other separation methods (Chaps. 8 - 10) 9: Adsorption and chromatography (Chap.11 and OHP) 10: Adsorption and chromatography (Chaps.11, 13 and OHP) EXAM Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography

  12. Heat and mass transfer film transfer coefficient overall transfer coefficient estimation of transfer coefficient heat exchanger mass transfer equipment Enzyme reaction Michaelis-Menten equation evaluation of kinetic parameters

  13. Biology Microbiology Biochemistry Genetic Engineering Week 1: Course introduction and Basic concepts (Chaps. 1 & 2) 2: Heat and mass transfer (Chaps. 5 & 6) 3: Fundamental reaction kinetics and enzyme reaction (Chap. 3) 4: Fundamentals of biochemistry and genetic engineering (OHP) 5: Cell kinetics and mode of fermentor operation (Chap. 4 & 12.6) 6: Bioreactors and fermentor design (Chap. 7) 7: Bioreactors and fermentation strategy (Chap. 7 & OHP) 8: Cell separation and other separation methods (Chaps. 8 - 10) 9: Adsorption and chromatography (Chap.11 and OHP) 10: Adsorption and chromatography (Chaps.11, 13 and OHP) EXAM Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography

  14. What are proteins ? How are proteins synthesizes ? Protein production in recombinant cells

  15. Biology Microbiology Biochemistry Genetic Engineering Week 1: Course introduction and Basic concepts (Chaps. 1 & 2) 2: Heat and mass transfer (Chaps. 5 & 6) 3: Fundamental reaction kinetics and enzyme reaction (Chap. 3) 4: Fundamentals of biochemistry and genetic engineering (OHP) 5: Cell kinetics and mode of fermentor operation (Chap. 4 & 12.6) 6: Bioreactors and fermentor design (Chap. 7) 7: Bioreactors and fermentation strategy (Chap. 7 & OHP) 8: Cell separation and other separation methods (Chaps. 8 - 10) 9: Adsorption and chromatography (Chap.11 and OHP) 10: Adsorption and chromatography (Chaps.11, 13 and OHP) EXAM Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography

  16. Cell growth kinetics batch culture fed-batch culture continuous culture production of target batch culture continuous culture

  17. Biology Microbiology Biochemistry Genetic Engineering Week 1: Course introduction and Basic concepts (Chaps. 1 & 2) 2: Heat and mass transfer (Chaps. 5 & 6) 3: Fundamental reaction kinetics and enzyme reaction (Chap. 3) 4: Fundamentals of biochemistry and genetic engineering (OHP) 5: Cell kinetics and mode of fermentor operation (Chap. 4 & 12.6) 6: Bioreactors and fermentor design (Chap. 7) 7: Bioreactors and fermentation strategy (Chap. 7 & OHP) 8: Cell separation and other separation methods (Chaps. 8 - 10) 9: Adsorption and chromatography (Chap.11 and OHP) 10: Adsorption and chromatography (Chaps.11, 13 and OHP) EXAM Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography

  18. Fermentor design operation mode stirred tank reactor power requirement oxygen transfer rate bubble column reactor oxygen transfer rate fermentation strategy fed-batch culture fermentor reservoir V (L) Feed medium＋Trace metal solution continuous culture

  19. Biology Microbiology Biochemistry Genetic Engineering Week 1: Course introduction and Basic concepts (Chaps. 1 & 2) 2: Heat and mass transfer (Chaps. 5 & 6) 3: Fundamental reaction kinetics and enzyme reaction (Chap. 3) 4: Fundamentals of biochemistry and genetic engineering (OHP) 5: Cell kinetics and mode of fermentor operation (Chap. 4 & 12.6) 6: Bioreactors and fermentor design (Chap. 7) 7: Bioreactors and fermentation strategy (Chap. 7 & OHP) 8: Cell separation and other separation methods (Chaps. 8 - 10) 9: Adsorption and chromatography (Chap.11 and OHP) 10: Adsorption and chromatography (Chaps.11, 13 and OHP) EXAM Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography

  20. Cell ceparation filtration centrifugation membrane separation

  21. Biology Microbiology Biochemistry Genetic Engineering Week 1: Course introduction and Basic concepts (Chaps. 1 & 2) 2: Heat and mass transfer (Chaps. 5 & 6) 3: Fundamental reaction kinetics and enzyme reaction (Chap. 3) 4: Fundamentals of biochemistry and genetic engineering (OHP) 5: Cell kinetics and mode of fermentor operation (Chap. 4 & 12.6) 6: Bioreactors and fermentor design (Chap. 7) 7: Bioreactors and fermentation strategy (Chap. 7 & OHP) 8: Cell separation and other separation methods (Chaps. 8 - 10) 9: Adsorption and chromatography (Chap.11 and OHP) 10: Adsorption and chromatography (Chaps.11, 13 and OHP) EXAM Chemical Engineering Thermodynamics Transport phenomena Reaction engineering Process control Biochemical Engineering Cell growth kinetics Reactor design Fermentation strategy Process control Bioseparation Cell separation Adsorption Chromatography

  22. Separation processes in bioindustry adsorption chromatography membrane separation application of immunointeraction antibody chromatography C time

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